SNAP25 (synaptosome associated protein 25)

2008-12-01  

Identity

HGNC
SNAP25
LOCATION
20p12.2
LOCUSID
6616
ALIAS
CMS18,RIC-4,RIC4,SEC9,SNAP,SNAP-25,SUP,bA416N4.2,dJ1068F16.2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 6616
MIM: 600322
HGNC: 11132
Ensembl: ENSG00000132639

Variants:

dbSNP: 6616
ClinVar: 6616
TCGA: ENSG00000132639
COSMIC: SNAP25

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000132639ENST00000254976P60880
ENSG00000132639ENST00000304886P60880
ENSG00000132639ENST00000430336A0A0A0MSS0

Expression (GTEx)

0
500
1000
1500
2000
2500
3000
3500
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Synaptic vesicle cycleKEGGko04721
Synaptic vesicle cycleKEGGhsa04721
Insulin secretionKEGGhsa04911
Neuronal SystemREACTOMER-HSA-112316
Transmission across Chemical SynapsesREACTOMER-HSA-112315
Neurotransmitter Release CycleREACTOMER-HSA-112310
Norepinephrine Neurotransmitter Release CycleREACTOMER-HSA-181430
Serotonin Neurotransmitter Release CycleREACTOMER-HSA-181429
Glutamate Neurotransmitter Release CycleREACTOMER-HSA-210500
Dopamine Neurotransmitter Release CycleREACTOMER-HSA-212676
Acetylcholine Neurotransmitter Release CycleREACTOMER-HSA-264642
GABA synthesis, release, reuptake and degradationREACTOMER-HSA-888590
DiseaseREACTOMER-HSA-1643685
Infectious diseaseREACTOMER-HSA-5663205
Uptake and actions of bacterial toxinsREACTOMER-HSA-5339562
Neurotoxicity of clostridium toxinsREACTOMER-HSA-168799
Toxicity of botulinum toxin type A (BoNT/A)REACTOMER-HSA-5250968
Toxicity of botulinum toxin type E (BoNT/E)REACTOMER-HSA-5250992
Toxicity of botulinum toxin type C (BoNT/C)REACTOMER-HSA-5250971
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
MetabolismREACTOMER-HSA-1430728
Integration of energy metabolismREACTOMER-HSA-163685
Regulation of insulin secretionREACTOMER-HSA-422356
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
366492682023miR-23a-3p and miR-181a-5p modulate SNAP-25 expression.1
368077632023Sex-specific effects of SNAP-25 genotype on verbal memory and Alzheimer's disease biomarkers in clinically normal older adults.1
373809512023Non-coding variants in VAMP2 and SNAP25 affect gene expression: potential implications in migraine susceptibility.0
374782202023Role of SNAP25 on the occurrence and development of eosinophilic gastritis.1
374914262023Impaired ATF3 signaling involves SNAP25 in SOD1 mutant ALS patients.1
377623422023The Role of SNAP-25 in Autism Spectrum Disorders Onset Patterns.1
381026102023Neuronal-specific TNFAIP1 ablation attenuates postoperative cognitive dysfunction via targeting SNAP25 for K48-linked ubiquitination.1
366492682023miR-23a-3p and miR-181a-5p modulate SNAP-25 expression.1
368077632023Sex-specific effects of SNAP-25 genotype on verbal memory and Alzheimer's disease biomarkers in clinically normal older adults.1
373809512023Non-coding variants in VAMP2 and SNAP25 affect gene expression: potential implications in migraine susceptibility.0
374782202023Role of SNAP25 on the occurrence and development of eosinophilic gastritis.1
374914262023Impaired ATF3 signaling involves SNAP25 in SOD1 mutant ALS patients.1
377623422023The Role of SNAP-25 in Autism Spectrum Disorders Onset Patterns.1
381026102023Neuronal-specific TNFAIP1 ablation attenuates postoperative cognitive dysfunction via targeting SNAP25 for K48-linked ubiquitination.1
330844942022Effects of the SNAP25 on Integration Ability of Brain Functions in Children With ADHD.4

Citation

Dessen P

SNAP25 (synaptosome associated protein 25)

Atlas Genet Cytogenet Oncol Haematol. 2008-12-01

Online version: http://atlasgeneticsoncology.org/gene/50575