Identity
HGNC
LOCATION
12p12.1
LOCUSID
ALIAS
OATP,OATP-A,OATP1A2,SLC21A3
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 6579
MIM: 602883
HGNC: 10956
Ensembl: ENSG00000084453
Variants:
dbSNP: 6579
ClinVar: 6579
TCGA: ENSG00000084453
COSMIC: SLCO1A2
RNA/Proteins
Expression (GTEx)
Pathways
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA10804 | imatinib | Chemical | ClinicalAnnotation | associated | PK | 21633340 | |
| PA133950441 | hmg coa reductase inhibitors | Chemical | Pathway | associated | |||
| PA164754992 | rocuronium | Chemical | ClinicalAnnotation | associated | PK | 28409297 | |
| PA446171 | Leukemia, Myelogenous, Chronic, BCR-ABL Positive | Disease | ClinicalAnnotation | associated | PK | 21633340 | |
| PA450428 | methotrexate | Chemical | Pathway | associated | 21317831 | ||
| PA450573 | nadolol | Chemical | Literature, MultilinkAnnotation | associated | 24419562 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38432624 | 2024 | The Effects of N-Glycosylation on the Expression and Transport Activity of OATP1A2 and OATP2B1. | 0 |
| 38432624 | 2024 | The Effects of N-Glycosylation on the Expression and Transport Activity of OATP1A2 and OATP2B1. | 0 |
| 34585840 | 2022 | Pharmacogenomics of celiprolol - evidence for a role of P-glycoprotein and organic anion transporting polypeptide 1A2 in celiprolol pharmacokinetics. | 2 |
| 36116173 | 2022 | Comparison of the transport kinetics of fexofenadine and its pH dependency among OATP1A2 genetic variants. | 0 |
| 34585840 | 2022 | Pharmacogenomics of celiprolol - evidence for a role of P-glycoprotein and organic anion transporting polypeptide 1A2 in celiprolol pharmacokinetics. | 2 |
| 36116173 | 2022 | Comparison of the transport kinetics of fexofenadine and its pH dependency among OATP1A2 genetic variants. | 0 |
| 33387348 | 2021 | SLC46A1 Haplotype with Predicted Functional Impact has Prognostic Value in Breast Carcinoma. | 2 |
| 34823432 | 2021 | Upregulation of OATP1A2 in human oesophageal squamous cell carcinoma cells via the HDAC6-GCN5/PCAF-H3K9Ac axis. | 0 |
| 33387348 | 2021 | SLC46A1 Haplotype with Predicted Functional Impact has Prognostic Value in Breast Carcinoma. | 2 |
| 34823432 | 2021 | Upregulation of OATP1A2 in human oesophageal squamous cell carcinoma cells via the HDAC6-GCN5/PCAF-H3K9Ac axis. | 0 |
| 32304147 | 2020 | Association between SLCO1A2 genetic variation and methotrexate toxicity in human rheumatoid arthritis treatment. | 3 |
| 32597704 | 2020 | Reabsorption of bile acids regulated by FXR-OATP1A2 is the main factor for the formation of cholesterol gallstone. | 5 |
| 32304147 | 2020 | Association between SLCO1A2 genetic variation and methotrexate toxicity in human rheumatoid arthritis treatment. | 3 |
| 32597704 | 2020 | Reabsorption of bile acids regulated by FXR-OATP1A2 is the main factor for the formation of cholesterol gallstone. | 5 |
| 29306656 | 2018 | Association between a microRNA binding site polymorphism in SLCO1A2 and the risk of delayed methotrexate elimination in Chinese children with acute lymphoblastic leukemia. | 8 |
Citation
Dessen P
SLCO1A2 (solute carrier organic anion transporter family member 1A2)
Atlas Genet Cytogenet Oncol Haematol. 2008-12-01
Online version: http://atlasgeneticsoncology.org/gene/50582/slco1a2
