DOCK10 (dedicator of cytokinesis 10)

2008-12-01  

Identity

HGNC
DOCK10
LOCATION
2q36.2
LOCUSID
55619
ALIAS
DRIP2,Nbla10300,ZIZ3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 55619
MIM: 611518
HGNC: 23479
Ensembl: ENSG00000135905

Variants:

dbSNP: 55619
ClinVar: 55619
TCGA: ENSG00000135905
COSMIC: DOCK10

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000135905ENST00000258390Q96BY6
ENSG00000135905ENST00000409592Q96BY6
ENSG00000135905ENST00000422684H7C0I3
ENSG00000135905ENST00000435582F8WE73
ENSG00000135905ENST00000458608F8WB48
ENSG00000135905ENST00000535663H0YFC5
ENSG00000135905ENST00000644695A0A2R8Y5U0
ENSG00000135905ENST00000645028A0A2R8YD85

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
HemostasisREACTOMER-HSA-109582
Factors involved in megakaryocyte development and platelet productionREACTOMER-HSA-983231

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
321123012020Expression of DOCK10.1 protein revealed with a specific antiserum: insights into regulation of first exon isoforms of DOCK10.3
321123012020Expression of DOCK10.1 protein revealed with a specific antiserum: insights into regulation of first exon isoforms of DOCK10.3
307282922019ERK2 regulates epithelial-to-mesenchymal plasticity through DOCK10-dependent Rac1/FoxO1 activation.47
307282922019ERK2 regulates epithelial-to-mesenchymal plasticity through DOCK10-dependent Rac1/FoxO1 activation.47
215143402011Human and mouse DOCK10 splicing isoforms with alternative first coding exon usage are differentially expressed in T and B lymphocytes.12
215143402011Human and mouse DOCK10 splicing isoforms with alternative first coding exon usage are differentially expressed in T and B lymphocytes.12
184992582008Dock10, a novel CZH protein selectively induced by interleukin-4 in human B lymphocytes.21
188351692008DOCK10-mediated Cdc42 activation is necessary for amoeboid invasion of melanoma cells.97
184992582008Dock10, a novel CZH protein selectively induced by interleukin-4 in human B lymphocytes.21
188351692008DOCK10-mediated Cdc42 activation is necessary for amoeboid invasion of melanoma cells.97

Citation

Dessen P

DOCK10 (dedicator of cytokinesis 10)

Atlas Genet Cytogenet Oncol Haematol. 2008-12-01

Online version: http://atlasgeneticsoncology.org/gene/50586/dock10