Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 113235
MIM: 611672
HGNC: 30521
Ensembl: ENSG00000076351
Variants:
dbSNP: 113235
ClinVar: 113235
TCGA: ENSG00000076351
COSMIC: SLC46A1
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA450428 | methotrexate | Chemical | Pathway | associated | 21317831 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 35811443 | 2022 | Loss of SLC46A1 decreases tumor iron content in hepatocellular carcinoma. | 5 |
| 35811443 | 2022 | Loss of SLC46A1 decreases tumor iron content in hepatocellular carcinoma. | 5 |
| 33387348 | 2021 | SLC46A1 Haplotype with Predicted Functional Impact has Prognostic Value in Breast Carcinoma. | 2 |
| 33737637 | 2021 | Folate transporter dynamics and therapy with classic and tumor-targeted antifolates. | 14 |
| 34040256 | 2021 | Structural basis of antifolate recognition and transport by PCFT. | 22 |
| 33387348 | 2021 | SLC46A1 Haplotype with Predicted Functional Impact has Prognostic Value in Breast Carcinoma. | 2 |
| 33737637 | 2021 | Folate transporter dynamics and therapy with classic and tumor-targeted antifolates. | 14 |
| 34040256 | 2021 | Structural basis of antifolate recognition and transport by PCFT. | 22 |
| 31926453 | 2020 | Decreased placental folate transporter expression and activity in first and second trimester in obese mothers. | 4 |
| 32493992 | 2020 | Impact of hypoxia on chemoresistance of mesothelioma mediated by the proton-coupled folate transporter, and preclinical activity of new anti-LDH-A compounds. | 12 |
| 32621820 | 2020 | SLC46A1 contributes to hepatic iron metabolism by importing heme in hepatocytes. | 8 |
| 32893190 | 2020 | A proton-coupled folate transporter mutation causing hereditary folate malabsorption locks the protein in an inward-open conformation. | 4 |
| 31926453 | 2020 | Decreased placental folate transporter expression and activity in first and second trimester in obese mothers. | 4 |
| 32493992 | 2020 | Impact of hypoxia on chemoresistance of mesothelioma mediated by the proton-coupled folate transporter, and preclinical activity of new anti-LDH-A compounds. | 12 |
| 32621820 | 2020 | SLC46A1 contributes to hepatic iron metabolism by importing heme in hepatocytes. | 8 |
Citation
Dessen P
SLC46A1 (solute carrier family 46 member 1)
Atlas Genet Cytogenet Oncol Haematol. 2008-12-01
Online version: http://atlasgeneticsoncology.org/gene/50593/slc46a1
