SORT1 (sortilin 1)

2009-01-01  

Identity

HGNC
LOCATION
1p13.3
LOCUSID
ALIAS
Gp95,LDLCQ6,NT3,NTR3
FUSION GENES

Other Information

Locus ID:

NCBI: 6272
MIM: 602458
HGNC: 11186
Ensembl: ENSG00000134243

Variants:

dbSNP: 6272
ClinVar: 6272
TCGA: ENSG00000134243
COSMIC: SORT1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000134243ENST00000256637Q99523
ENSG00000134243ENST00000471996A0A0J9YVU2
ENSG00000134243ENST00000482236A0A0J9YVX1
ENSG00000134243ENST00000493736A0A0J9YX61
ENSG00000134243ENST00000538502Q99523
ENSG00000134243ENST00000633956A0A0J9YY30

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
LysosomeKEGGko04142
LysosomeKEGGhsa04142
Neurotrophin signaling pathwayKEGGko04722
Neurotrophin signaling pathwayKEGGhsa04722
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
trans-Golgi Network Vesicle BuddingREACTOMER-HSA-199992
Clathrin derived vesicle buddingREACTOMER-HSA-421837
Golgi Associated Vesicle BiogenesisREACTOMER-HSA-432722

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
380955572024The association of Sort1 expression with LDL subfraction and inflammation in patients with coronary artery disease.0
383390692024Sortilin Expression Levels and Peripheral Immunity: A Potential Biomarker for Segregation between Parkinson's Disease Patients and Healthy Controls.0
386949402024Elevated sortilin expression discriminates functional from non-functional neuroendocrine tumors and enables therapeutic targeting.0
380955572024The association of Sort1 expression with LDL subfraction and inflammation in patients with coronary artery disease.0
383390692024Sortilin Expression Levels and Peripheral Immunity: A Potential Biomarker for Segregation between Parkinson's Disease Patients and Healthy Controls.0
386949402024Elevated sortilin expression discriminates functional from non-functional neuroendocrine tumors and enables therapeutic targeting.0
354035112023Serum sortilin as a predictor of stroke in patients with intermediate carotid artery stenosis.0
360894172023Aberrant protein expression of Appl1, Sortilin and Syndecan-1 during the biological progression of prostate cancer.8
375795652023Inductive effect of SORT1 on odontoblastic differentiation of human dental pulp-derived stem cells.0
375963052023Dynamic interplay between sortilin and syndecan-1 contributes to prostate cancer progression.2
376733282023Sortilin-Driven Cancer Secretome Enhances Tumorigenic Properties of Hepatocellular Carcinoma via de Novo Lipogenesis.1
379139952023Missense variants in SORT1 are associated with LDL-C in an Amish population.0
354035112023Serum sortilin as a predictor of stroke in patients with intermediate carotid artery stenosis.0
360894172023Aberrant protein expression of Appl1, Sortilin and Syndecan-1 during the biological progression of prostate cancer.8
375795652023Inductive effect of SORT1 on odontoblastic differentiation of human dental pulp-derived stem cells.0

Citation

Dessen P

SORT1 (sortilin 1)

Atlas Genet Cytogenet Oncol Haematol. 2009-01-01

Online version: http://atlasgeneticsoncology.org/gene/50638/sort1