ACSL5 (acyl-CoA synthetase long chain family member 5)

2009-02-01  

Identity

HGNC
LOCATION
10q25.2
LOCUSID
ALIAS
ACS2,ACS5,FACL5
FUSION GENES

Other Information

Locus ID:

NCBI: 51703
MIM: 605677
HGNC: 16526
Ensembl: ENSG00000197142

Variants:

dbSNP: 51703
ClinVar: 51703
TCGA: ENSG00000197142
COSMIC: ACSL5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000197142ENST00000354273Q9ULC5
ENSG00000197142ENST00000354655Q9ULC5
ENSG00000197142ENST00000356116Q9ULC5
ENSG00000197142ENST00000393081Q9ULC5
ENSG00000197142ENST00000433418Q9ULC5

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100

Pathways

PathwaySourceExternal ID
Fatty acid biosynthesisKEGGko00061
Fatty acid degradationKEGGko00071
PPAR signaling pathwayKEGGko03320
Adipocytokine signaling pathwayKEGGko04920
Fatty acid biosynthesisKEGGhsa00061
Fatty acid degradationKEGGhsa00071
PPAR signaling pathwayKEGGhsa03320
Adipocytokine signaling pathwayKEGGhsa04920
PeroxisomeKEGGko04146
PeroxisomeKEGGhsa04146
Metabolic pathwaysKEGGhsa01100
beta-Oxidation, acyl-CoA synthesisKEGGhsa_M00086
beta-Oxidation, acyl-CoA synthesisKEGGM00086
Fatty acid metabolismKEGGhsa01212
Fatty acid metabolismKEGGko01212
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Fatty acid, triacylglycerol, and ketone body metabolismREACTOMER-HSA-535734
Triglyceride BiosynthesisREACTOMER-HSA-75109
Fatty Acyl-CoA BiosynthesisREACTOMER-HSA-75105
Synthesis of very long-chain fatty acyl-CoAsREACTOMER-HSA-75876
FerroptosisKEGGko04216
FerroptosisKEGGhsa04216

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
366398362023Lysophosphatidylcholine inhibits lung cancer cell proliferation by regulating fatty acid metabolism enzyme long-chain acyl-coenzyme A synthase 5.4
368803052023More than just a histone deacetylase: cytoplasmic SIRT6 facilitates fatty acid oxidation through ACSL5 deacetylation.0
369321152023Hypoxia-responsive PPARGC1A/BAMBI/ACSL5 axis promotes progression and resistance to lenvatinib in hepatocellular carcinoma.11
371310852023ACSL5, a prognostic factor in acute myeloid leukemia, modulates the activity of Wnt/β-catenin signaling by palmitoylation modification.3
366398362023Lysophosphatidylcholine inhibits lung cancer cell proliferation by regulating fatty acid metabolism enzyme long-chain acyl-coenzyme A synthase 5.4
368803052023More than just a histone deacetylase: cytoplasmic SIRT6 facilitates fatty acid oxidation through ACSL5 deacetylation.0
369321152023Hypoxia-responsive PPARGC1A/BAMBI/ACSL5 axis promotes progression and resistance to lenvatinib in hepatocellular carcinoma.11
371310852023ACSL5, a prognostic factor in acute myeloid leukemia, modulates the activity of Wnt/β-catenin signaling by palmitoylation modification.3
323474122021Roles of acyl-CoA synthetase long-chain family member 5 and colony stimulating factor 2 in inhibition of palmitic or stearic acids in lung cancer cell proliferation and metabolism.13
331915002021Deficiency of acyl-CoA synthetase 5 is associated with a severe and treatable failure to thrive of neonatal onset.4
348598672021The gene variant rs2419621 of ACYL-CoA synthetase long-chain 5 gene is associated with weight loss and metabolic changes in response to a robotic sleeve gastrectomy in morbid obese subjects.2
323474122021Roles of acyl-CoA synthetase long-chain family member 5 and colony stimulating factor 2 in inhibition of palmitic or stearic acids in lung cancer cell proliferation and metabolism.13
331915002021Deficiency of acyl-CoA synthetase 5 is associated with a severe and treatable failure to thrive of neonatal onset.4
348598672021The gene variant rs2419621 of ACYL-CoA synthetase long-chain 5 gene is associated with weight loss and metabolic changes in response to a robotic sleeve gastrectomy in morbid obese subjects.2
320122652020miR-497-5p mediates starvation-induced death in colon cancer cells by targeting acyl-CoA synthetase-5 and modulation of lipid metabolism.22

Citation

Dessen P

ACSL5 (acyl-CoA synthetase long chain family member 5)

Atlas Genet Cytogenet Oncol Haematol. 2009-02-01

Online version: http://atlasgeneticsoncology.org/gene/50668/acsl5