CRHR2 (corticotropin releasing hormone receptor 2)

2009-03-01 Affiliation

Identity

HGNC

CRHR2

LOCATION

7p14.3

LOCUSID

1395

ALIAS

CRF-RB,CRF2,CRFR2,HM-CRF

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 1395
MIM: 602034
HGNC: 2358
Ensembl: ENSG00000106113

Variants:

dbSNP: 1395
ClinVar: 1395
TCGA: ENSG00000106113
COSMIC: CRHR2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000106113	ENST00000341843	Q13324
ENSG00000106113	ENST00000348438	Q13324
ENSG00000106113	ENST00000423776	F2Z2M6
ENSG00000106113	ENST00000445981	C9JZM9
ENSG00000106113	ENST00000452278	F2Z2M6
ENSG00000106113	ENST00000471646	Q13324
ENSG00000106113	ENST00000471646	A0A090N7T4
ENSG00000106113	ENST00000506074	Q13324

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Neuroactive ligand-receptor interaction	KEGG	ko04080
Neuroactive ligand-receptor interaction	KEGG	hsa04080
Metabolism of proteins	REACTOME	R-HSA-392499
Peptide hormone metabolism	REACTOME	R-HSA-2980736
Synthesis, secretion, and deacylation of Ghrelin	REACTOME	R-HSA-422085
Signal Transduction	REACTOME	R-HSA-162582
Signaling by GPCR	REACTOME	R-HSA-372790
GPCR ligand binding	REACTOME	R-HSA-500792
Class B/2 (Secretin family receptors)	REACTOME	R-HSA-373080
GPCR downstream signaling	REACTOME	R-HSA-388396
G alpha (s) signalling events	REACTOME	R-HSA-418555

PharmGKB

Entity ID	Name	Type	Evidence	Association	PD	PMIDs
PA134687887	selective beta-2-adrenoreceptor agonists	Chemical	ClinicalAnnotation	associated	PD
PA443450	Asthma	Disease	ClinicalAnnotation	associated	PD
PA447321	Depressive Disorder, Major	Disease	ClinicalAnnotation	associated	PD	17467808
PA448068	salbutamol	Chemical	ClinicalAnnotation	associated	PD
PA449015	citalopram	Chemical	ClinicalAnnotation	associated	PD	17467808

References

Pubmed ID	Year	Title	Citations
37543650	2023	Novel corticotropin-releasing hormone receptor genes (CRHR1 and CRHR2) linkage to and association with polycystic ovary syndrome.	1
37543650	2023	Novel corticotropin-releasing hormone receptor genes (CRHR1 and CRHR2) linkage to and association with polycystic ovary syndrome.	1
34969780	2022	Association between genetic variant rs2267716 of CRHR2 gene with colorectal cancer.	2
35093492	2022	Defects in NLRP6, autophagy and goblet cell homeostasis are associated with reduced duodenal CRH receptor 2 expression in patients with functional dyspepsia.	6
36077219	2022	Comorbidity of Novel CRHR2 Gene Variants in Type 2 Diabetes and Depression.	5
34969780	2022	Association between genetic variant rs2267716 of CRHR2 gene with colorectal cancer.	2
35093492	2022	Defects in NLRP6, autophagy and goblet cell homeostasis are associated with reduced duodenal CRH receptor 2 expression in patients with functional dyspepsia.	6
36077219	2022	Comorbidity of Novel CRHR2 Gene Variants in Type 2 Diabetes and Depression.	5
31882463	2020	Hypermethylation of Corticotropin Releasing Hormone Receptor-2 Gene in Ulcerative Colitis Associated Colorectal Cancer.	3
32057826	2020	Different effects of chronic social defeat on social behavior and the brain CRF system in adult male C57 mice with different susceptibilities.	4
31882463	2020	Hypermethylation of Corticotropin Releasing Hormone Receptor-2 Gene in Ulcerative Colitis Associated Colorectal Cancer.	3
32057826	2020	Different effects of chronic social defeat on social behavior and the brain CRF system in adult male C57 mice with different susceptibilities.	4
30584229	2019	Corticotropin-Releasing Hormone Family and Their Receptors in the Cardiovascular System.	7
30704133	2019	Plasma Corticotropin-Releasing Factor Receptors and B7-2⁺ Extracellular Vesicles in Blood Correlate with Irritable Bowel Syndrome Disease Severity.	8
30849520	2019	Activated CRH receptors inhibit autophagy by repressing conversion of LC3BI to LC3BII.	6

Citation

Dessen P

CRHR2 (corticotropin releasing hormone receptor 2)

Atlas Genet Cytogenet Oncol Haematol. 2009-03-01

Online version: http://atlasgeneticsoncology.org/gene/50691/cancer-prone-explorer/favicon/manifest.json