Identity
HGNC
LOCATION
7p14.3
LOCUSID
ALIAS
CRF-RB,CRF2,CRFR2,HM-CRF
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 1395
MIM: 602034
HGNC: 2358
Ensembl: ENSG00000106113
Variants:
dbSNP: 1395
ClinVar: 1395
TCGA: ENSG00000106113
COSMIC: CRHR2
RNA/Proteins
Expression (GTEx)
Pathways
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA134687887 | selective beta-2-adrenoreceptor agonists | Chemical | ClinicalAnnotation | associated | PD | ||
| PA443450 | Asthma | Disease | ClinicalAnnotation | associated | PD | ||
| PA447321 | Depressive Disorder, Major | Disease | ClinicalAnnotation | associated | PD | 17467808 | |
| PA448068 | salbutamol | Chemical | ClinicalAnnotation | associated | PD | ||
| PA449015 | citalopram | Chemical | ClinicalAnnotation | associated | PD | 17467808 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37543650 | 2023 | Novel corticotropin-releasing hormone receptor genes (CRHR1 and CRHR2) linkage to and association with polycystic ovary syndrome. | 1 |
| 37543650 | 2023 | Novel corticotropin-releasing hormone receptor genes (CRHR1 and CRHR2) linkage to and association with polycystic ovary syndrome. | 1 |
| 34969780 | 2022 | Association between genetic variant rs2267716 of CRHR2 gene with colorectal cancer. | 2 |
| 35093492 | 2022 | Defects in NLRP6, autophagy and goblet cell homeostasis are associated with reduced duodenal CRH receptor 2 expression in patients with functional dyspepsia. | 6 |
| 36077219 | 2022 | Comorbidity of Novel CRHR2 Gene Variants in Type 2 Diabetes and Depression. | 5 |
| 34969780 | 2022 | Association between genetic variant rs2267716 of CRHR2 gene with colorectal cancer. | 2 |
| 35093492 | 2022 | Defects in NLRP6, autophagy and goblet cell homeostasis are associated with reduced duodenal CRH receptor 2 expression in patients with functional dyspepsia. | 6 |
| 36077219 | 2022 | Comorbidity of Novel CRHR2 Gene Variants in Type 2 Diabetes and Depression. | 5 |
| 31882463 | 2020 | Hypermethylation of Corticotropin Releasing Hormone Receptor-2 Gene in Ulcerative Colitis Associated Colorectal Cancer. | 3 |
| 32057826 | 2020 | Different effects of chronic social defeat on social behavior and the brain CRF system in adult male C57 mice with different susceptibilities. | 4 |
| 31882463 | 2020 | Hypermethylation of Corticotropin Releasing Hormone Receptor-2 Gene in Ulcerative Colitis Associated Colorectal Cancer. | 3 |
| 32057826 | 2020 | Different effects of chronic social defeat on social behavior and the brain CRF system in adult male C57 mice with different susceptibilities. | 4 |
| 30584229 | 2019 | Corticotropin-Releasing Hormone Family and Their Receptors in the Cardiovascular System. | 7 |
| 30704133 | 2019 | Plasma Corticotropin-Releasing Factor Receptors and B7-2⁺ Extracellular Vesicles in Blood Correlate with Irritable Bowel Syndrome Disease Severity. | 8 |
| 30849520 | 2019 | Activated CRH receptors inhibit autophagy by repressing conversion of LC3BI to LC3BII. | 6 |
Citation
Dessen P
CRHR2 (corticotropin releasing hormone receptor 2)
Atlas Genet Cytogenet Oncol Haematol. 2009-03-01
Online version: http://atlasgeneticsoncology.org/gene/50691/crhr2
