CPSF3 (cleavage and polyadenylation specific factor 3)

2009-03-01  

Identity

HGNC
CPSF3
LOCATION
2p25.1
LOCUSID
51692
ALIAS
CPSF-73,CPSF73
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 51692
MIM: 606029
HGNC: 2326
Ensembl: ENSG00000119203

Variants:

dbSNP: 51692
ClinVar: 51692
TCGA: ENSG00000119203
COSMIC: CPSF3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000119203ENST00000238112Q9UKF6
ENSG00000119203ENST00000460593G5E9W3
ENSG00000119203ENST00000475482C9JZH6

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
mRNA surveillance pathwayKEGGko03015
mRNA surveillance pathwayKEGGhsa03015
Gene ExpressionREACTOMER-HSA-74160
RNA Polymerase II TranscriptionREACTOMER-HSA-73857
RNA Polymerase II Transcription TerminationREACTOMER-HSA-73856
Cleavage of Growing Transcript in the Termination RegionREACTOMER-HSA-109688
Processing of Capped Intron-Containing Pre-mRNAREACTOMER-HSA-72203
mRNA SplicingREACTOMER-HSA-72172
mRNA Splicing - Major PathwayREACTOMER-HSA-72163
mRNA 3'-end processingREACTOMER-HSA-72187
Transport of Mature Transcript to CytoplasmREACTOMER-HSA-72202
Transport of Mature mRNAs Derived from Intronless TranscriptsREACTOMER-HSA-159234
Transport of Mature mRNA Derived from an Intronless TranscriptREACTOMER-HSA-159231
Processing of Capped Intronless Pre-mRNAREACTOMER-HSA-75067
Processing of Intronless Pre-mRNAsREACTOMER-HSA-77595

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
381911712024CPSF3 inhibition blocks pancreatic cancer cell proliferation through disruption of core histone mRNA processing.0
387188872024CPSF3 regulates alternative polyadenylation of CNIH2 to promote esophageal squamous cell carcinoma progression.0
381911712024CPSF3 inhibition blocks pancreatic cancer cell proliferation through disruption of core histone mRNA processing.0
387188872024CPSF3 regulates alternative polyadenylation of CNIH2 to promote esophageal squamous cell carcinoma progression.0
368223272023An examination of the metal ion content in the active sites of human endonucleases CPSF73 and INTS11.2
379921782023Therapeutic targeting of CPSF3-dependent transcriptional termination in ovarian cancer.1
368223272023An examination of the metal ion content in the active sites of human endonucleases CPSF73 and INTS11.2
379921782023Therapeutic targeting of CPSF3-dependent transcriptional termination in ovarian cancer.1
351217502022Population-level deficit of homozygosity unveils CPSF3 as an intellectual disability syndrome gene.5
351217502022Population-level deficit of homozygosity unveils CPSF3 as an intellectual disability syndrome gene.5
336665192021Cleavage and polyadenylation-specific factor 3 induces cell cycle arrest via PI3K/Akt/GSK-3β signaling pathways and predicts a negative prognosis in hepatocellular carcinoma.2
342300592021A real-time fluorescence assay for CPSF73, the nuclease for pre-mRNA 3'-end processing.5
336665192021Cleavage and polyadenylation-specific factor 3 induces cell cycle arrest via PI3K/Akt/GSK-3β signaling pathways and predicts a negative prognosis in hepatocellular carcinoma.2
342300592021A real-time fluorescence assay for CPSF73, the nuclease for pre-mRNA 3'-end processing.5
318192762020CPSF3-dependent pre-mRNA processing as a druggable node in AML and Ewing's sarcoma.32

Citation

Dessen P

CPSF3 (cleavage and polyadenylation specific factor 3)

Atlas Genet Cytogenet Oncol Haematol. 2009-03-01

Online version: http://atlasgeneticsoncology.org/gene/50692