SLC39A2 (solute carrier family 39 member 2)

2009-03-01  

Identity

HGNC
LOCATION
14q11.2
LOCUSID
ALIAS
6A1,ETI-1,ZIP-2,ZIP2

Other Information

Locus ID:

NCBI: 29986
MIM: 612166
HGNC: 17127
Ensembl: ENSG00000165794

Variants:

dbSNP: 29986
ClinVar: 29986
TCGA: ENSG00000165794
COSMIC: SLC39A2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000165794ENST00000298681Q9NP94
ENSG00000165794ENST00000554422Q9NP94

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compoundsREACTOMER-HSA-425366
Metal ion SLC transportersREACTOMER-HSA-425410
Zinc transportersREACTOMER-HSA-435354
Zinc influx into cells by the SLC39 gene familyREACTOMER-HSA-442380

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
309144782019Unraveling the structural elements of pH sensitivity and substrate binding in the human zinc transporter SLC39A2 (ZIP2).11
309144782019Unraveling the structural elements of pH sensitivity and substrate binding in the human zinc transporter SLC39A2 (ZIP2).11
292895322018Zinc Deficiency via a Splice Switch in Zinc Importer ZIP2/SLC39A2 Causes Cystic Fibrosis-Associated MUC5AC Hypersecretion in Airway Epithelial Cells.15
297911422018Reassessment of the Transport Mechanism of the Human Zinc Transporter SLC39A2.15
292895322018Zinc Deficiency via a Splice Switch in Zinc Importer ZIP2/SLC39A2 Causes Cystic Fibrosis-Associated MUC5AC Hypersecretion in Airway Epithelial Cells.15
297911422018Reassessment of the Transport Mechanism of the Human Zinc Transporter SLC39A2.15
283456602017Zinc deficiency and low enterocyte zinc transporter expression in human patients with autism related mutations in SHANK3.30
283456602017Zinc deficiency and low enterocyte zinc transporter expression in human patients with autism related mutations in SHANK3.30
266439242015Effect of ZIP2 Gln/Arg/Leu (rs2234632) polymorphism on zinc homeostasis and inflammatory response following zinc supplementation.5
266439242015Effect of ZIP2 Gln/Arg/Leu (rs2234632) polymorphism on zinc homeostasis and inflammatory response following zinc supplementation.5
249360572014ZIP2 protein, a zinc transporter, is associated with keratinocyte differentiation.27
249360572014ZIP2 protein, a zinc transporter, is associated with keratinocyte differentiation.27
236861082013Up-regulation of Slc39A2(Zip2) mRNA in peripheral blood mononuclear cells from patients with pulmonary tuberculosis.5
239214842013Zip1, Zip2, and Zip8 mRNA expressions were associated with growth hormone level during the growth hormone provocation test in children with short stature.6
236861082013Up-regulation of Slc39A2(Zip2) mRNA in peripheral blood mononuclear cells from patients with pulmonary tuberculosis.5

Citation

Dessen P

SLC39A2 (solute carrier family 39 member 2)

Atlas Genet Cytogenet Oncol Haematol. 2009-03-01

Online version: http://atlasgeneticsoncology.org/gene/50696/slc39a2