FSHR (follicle stimulating hormone receptor)

2003-11-01  

Identity

HGNC
FSHR
LOCATION
2p16.3
LOCUSID
2492
ALIAS
FSHR1,FSHRO,LGR1,ODG1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 2492
MIM: 136435
HGNC: 3969
Ensembl: ENSG00000170820

Variants:

dbSNP: 2492
ClinVar: 2492
TCGA: ENSG00000170820
COSMIC: FSHR

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000170820ENST00000304421P23945
ENSG00000170820ENST00000406846A0A1D5RMN4
ENSG00000170820ENST00000419927F8WBM4
ENSG00000170820ENST00000454032C9JDA1

Expression (GTEx)

0
1
2
3
4
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Neuroactive ligand-receptor interactionKEGGhsa04080
Ovarian steroidogenesisKEGGhsa04913
Ovarian steroidogenesisKEGGko04913
cAMP signaling pathwayKEGGhsa04024
cAMP signaling pathwayKEGGko04024
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Hormone ligand-binding receptorsREACTOMER-HSA-375281
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (s) signalling eventsREACTOMER-HSA-418555

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA164746560thyrotropin alfaChemicalClinicalAnnotationassociatedPKPD21121812
PA165108853Ovarian hyperstimulation syndromeDiseaseClinicalAnnotationassociatedPKPD21121812
PA444618Infertility, FemaleDiseaseClinicalAnnotationassociatedPKPD21121812
PA449693follitropin betaChemicalClinicalAnnotationassociatedPKPD21121812
PA451835urofollitropinChemicalClinicalAnnotationassociatedPKPD21121812

References

Pubmed IDYearTitleCitations
386645372024Prevalence of FSH-R Asn680Ser and Ala307Thr receptor polymorphism and their correlation with ART outcomes among infertile Indian-Asian women-a prospective cohort study.0
386645372024Prevalence of FSH-R Asn680Ser and Ala307Thr receptor polymorphism and their correlation with ART outcomes among infertile Indian-Asian women-a prospective cohort study.0
356807252023The Effect of the Allelics of Ser680Asn Polymorphisms of Follicle-Stimulating Hormone Receptor Gene in IVF/ICSI Cycles: a Systematic Review and Meta-analysis.2
363509752023Association of FSHR and DENND1A polymorphisms with polycystic ovary syndrome: a meta-analysis.1
368210342023Analyzing the Impact of FSHR Variants on Polycystic Ovary Syndrome-a Case-Control Study in Punjab.5
371306232023Association between sequence variants in the FSHR gene and reproductive outcomes following IVF in predicted normoresponders.0
372281562023Exploring the expression and potential function of follicle stimulating hormone receptor in extragonadal cells related to abdominal aortic aneurysm.0
372871862023Ala307Thr variation modulates FSHR structure and impairs its binding affinity for FSH: Implications in polycystic ovarian syndrome.0
376534122023Polymorphisms in FSHR modulating susceptibility to polycystic ovary syndrome: an updated meta-analysis.0
356807252023The Effect of the Allelics of Ser680Asn Polymorphisms of Follicle-Stimulating Hormone Receptor Gene in IVF/ICSI Cycles: a Systematic Review and Meta-analysis.2
363509752023Association of FSHR and DENND1A polymorphisms with polycystic ovary syndrome: a meta-analysis.1
368210342023Analyzing the Impact of FSHR Variants on Polycystic Ovary Syndrome-a Case-Control Study in Punjab.5
371306232023Association between sequence variants in the FSHR gene and reproductive outcomes following IVF in predicted normoresponders.0
372281562023Exploring the expression and potential function of follicle stimulating hormone receptor in extragonadal cells related to abdominal aortic aneurysm.0
372871862023Ala307Thr variation modulates FSHR structure and impairs its binding affinity for FSH: Implications in polycystic ovarian syndrome.0

Citation

Dessen P

FSHR (follicle stimulating hormone receptor)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/507/favicon/haematological-explorer/js/template.js