HNRNPM (heterogeneous nuclear ribonucleoprotein M)

2009-03-01  

Identity

HGNC
HNRNPM
LOCATION
19p13.2
LOCUSID
4670
ALIAS
CEAR,HNRNPM4,HNRPM,HNRPM4,HTGR1,NAGR1,hnRNP
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 4670
MIM: 160994
HGNC: 5046
Ensembl: ENSG00000099783

Variants:

dbSNP: 4670
ClinVar: 4670
TCGA: ENSG00000099783
COSMIC: HNRNPM

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000099783ENST00000325495P52272
ENSG00000099783ENST00000348943P52272
ENSG00000099783ENST00000594907M0R2T0
ENSG00000099783ENST00000596295M0R2I7
ENSG00000099783ENST00000596984M0QYQ7
ENSG00000099783ENST00000597270M0QZM1
ENSG00000099783ENST00000598367M0QYL3
ENSG00000099783ENST00000598999M0QY96
ENSG00000099783ENST00000600092M0R019
ENSG00000099783ENST00000600806M0R0Y6
ENSG00000099783ENST00000601645M0R0N3
ENSG00000099783ENST00000620401A0A087X0X3

Expression (GTEx)

0
50
100
150
200
250
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
SpliceosomeKEGGko03040
SpliceosomeKEGGhsa03040
Signal TransductionREACTOMER-HSA-162582
Signaling by FGFRREACTOMER-HSA-190236
Signaling by FGFR2REACTOMER-HSA-5654738
Gene ExpressionREACTOMER-HSA-74160
Processing of Capped Intron-Containing Pre-mRNAREACTOMER-HSA-72203
mRNA SplicingREACTOMER-HSA-72172
mRNA Splicing - Major PathwayREACTOMER-HSA-72163
FGFR2 alternative splicingREACTOMER-HSA-6803529

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
388155792024hnRNPM protects against the dsRNA-mediated interferon response by repressing LINE-associated cryptic splicing.0
390344022024PARP4 interacts with hnRNPM to regulate splicing during lung cancer progression.1
388155792024hnRNPM protects against the dsRNA-mediated interferon response by repressing LINE-associated cryptic splicing.0
390344022024PARP4 interacts with hnRNPM to regulate splicing during lung cancer progression.1
380168152023Knockdown of HNRNPM inhibits the progression of glioma through inducing ferroptosis.0
380168152023Knockdown of HNRNPM inhibits the progression of glioma through inducing ferroptosis.0
351580982022Targeting HNRNPM Inhibits Cancer Stemness and Enhances Antitumor Immunity in Wnt-activated Hepatocellular Carcinoma.9
351580982022Targeting HNRNPM Inhibits Cancer Stemness and Enhances Antitumor Immunity in Wnt-activated Hepatocellular Carcinoma.9
340758782021HNRNPM controls circRNA biogenesis and splicing fidelity to sustain cancer cell fitness.23
342447932021RBFOX2 alters splicing outcome in distinct binding modes with multiple protein partners.19
343853092021CircURI1 interacts with hnRNPM to inhibit metastasis by modulating alternative splicing in gastric cancer.57
340758782021HNRNPM controls circRNA biogenesis and splicing fidelity to sustain cancer cell fitness.23
342447932021RBFOX2 alters splicing outcome in distinct binding modes with multiple protein partners.19
343853092021CircURI1 interacts with hnRNPM to inhibit metastasis by modulating alternative splicing in gastric cancer.57
329400782020microR-505/heterogeneous nuclear ribonucleoprotein M inhibits hepatocellular carcinoma cell proliferation and induces cell apoptosis through the Wnt/β-catenin signaling pathway.1

Citation

Dessen P

HNRNPM (heterogeneous nuclear ribonucleoprotein M)

Atlas Genet Cytogenet Oncol Haematol. 2009-03-01

Online version: http://atlasgeneticsoncology.org/gene/50719/gene-fusions-explorer/gene-explorer/favicon/favicon-32x32.png