CYP4F3 (cytochrome P450 family 4 subfamily F member 3)

2009-03-01  

Identity

HGNC
CYP4F3
LOCATION
19p13.12
LOCUSID
4051
ALIAS
CPF3,CYP4F,CYPIVF3,LTB4H
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 4051
MIM: 601270
HGNC: 2646
Ensembl: ENSG00000186529

Variants:

dbSNP: 4051
ClinVar: 4051
TCGA: ENSG00000186529
COSMIC: CYP4F3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000186529ENST00000221307Q08477
ENSG00000186529ENST00000221307A0A024R7J8
ENSG00000186529ENST00000585846Q08477
ENSG00000186529ENST00000585846A0A024R7I2
ENSG00000186529ENST00000586182Q08477
ENSG00000186529ENST00000586182A0A024R7I2
ENSG00000186529ENST00000587360K7EJZ8
ENSG00000186529ENST00000591058Q08477
ENSG00000186529ENST00000591058A0A024R7I2
ENSG00000186529ENST00000592424V9GYA1

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Arachidonic acid metabolismKEGGko00590
Arachidonic acid metabolismKEGGhsa00590
Metabolic pathwaysKEGGhsa01100
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Arachidonic acid metabolismREACTOMER-HSA-2142753
Synthesis of Leukotrienes (LT) and Eoxins (EX)REACTOMER-HSA-2142691
Biological oxidationsREACTOMER-HSA-211859
Phase 1 - Functionalization of compoundsREACTOMER-HSA-211945
Cytochrome P450 - arranged by substrate typeREACTOMER-HSA-211897
Fatty acidsREACTOMER-HSA-211935
EicosanoidsREACTOMER-HSA-211979
Miscellaneous substratesREACTOMER-HSA-211958

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
281508782017Pathway-analysis of published genome-wide association studies of lung cancer: A potential role for the CYP4F3 locus.8
289918562017Genetic Polymorphisms in Fatty Acid Metabolism Modify the Association Between Dietary n3: n6 Intake and Risk of Ulcerative Colitis: A Prospective Cohort Study.22
281508782017Pathway-analysis of published genome-wide association studies of lung cancer: A potential role for the CYP4F3 locus.8
289918562017Genetic Polymorphisms in Fatty Acid Metabolism Modify the Association Between Dietary n3: n6 Intake and Risk of Ulcerative Colitis: A Prospective Cohort Study.22
244064702014Interactions between the dietary polyunsaturated fatty acid ratio and genetic factors determine susceptibility to pediatric Crohn's disease.43
244064702014Interactions between the dietary polyunsaturated fatty acid ratio and genetic factors determine susceptibility to pediatric Crohn's disease.43
227062302012Human cytochrome P450 4F3: structure, functions, and prospects.11
227062302012Human cytochrome P450 4F3: structure, functions, and prospects.11
200475212010LTB4 can stimulate human osteoclast differentiation dependent of RANKL.6
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.37
200475212010LTB4 can stimulate human osteoclast differentiation dependent of RANKL.6
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.37
193430462009Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects.4
193430462009Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects.4
180657492008Omega oxidation of 3-hydroxy fatty acids by the human CYP4F gene subfamily enzyme CYP4F11.24

Citation

Dessen P

CYP4F3 (cytochrome P450 family 4 subfamily F member 3)

Atlas Genet Cytogenet Oncol Haematol. 2009-03-01

Online version: http://atlasgeneticsoncology.org/gene/50797/teaching-explorer/css/lib/haematological-explorer/