CPEB1 (cytoplasmic polyadenylation element binding protein 1)

2009-03-01 Affiliation

Identity

HGNC

CPEB1

LOCATION

15q25.2

LOCUSID

64506

ALIAS

CPE-BP1,CPEB,CPEB-1,h-CPEB,hCPEB-1

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 64506
MIM: 607342
HGNC: 21744
Ensembl: ENSG00000214575

Variants:

dbSNP: 64506
ClinVar: 64506
TCGA: ENSG00000214575
COSMIC: CPEB1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000214575	ENST00000567678	H3BTE4
ENSG00000214575	ENST00000568994	H3BNX1
ENSG00000214575	ENST00000569257	H3BPD6
ENSG00000214575	ENST00000611031	A0A087X171
ENSG00000214575	ENST00000611163	Q9BZB8
ENSG00000214575	ENST00000614918	A0A087WXG7
ENSG00000214575	ENST00000614977	A0A087WUQ9
ENSG00000214575	ENST00000615198	Q9BZB8
ENSG00000214575	ENST00000616959	A0A087WVR7
ENSG00000214575	ENST00000617462	Q9BZB8
ENSG00000214575	ENST00000617522	Q9BZB8
ENSG00000214575	ENST00000617958	A0A024R214
ENSG00000214575	ENST00000618449	Q9BZB8
ENSG00000214575	ENST00000620182	Q9BZB8

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Dorso-ventral axis formation	KEGG	ko04320
Progesterone-mediated oocyte maturation	KEGG	ko04914
Dorso-ventral axis formation	KEGG	hsa04320
Progesterone-mediated oocyte maturation	KEGG	hsa04914
Oocyte meiosis	KEGG	ko04114
Oocyte meiosis	KEGG	hsa04114

References

Pubmed ID	Year	Title	Citations
33162033	2021	Estrogen promotes increased breast cancer cell proliferation and migration through downregulation of CPEB1 expression.	3
33892791	2021	DNA hypermethylation contributes to colorectal cancer metastasis by regulating the binding of CEBPB and TFCP2 to the CPEB1 promoter.	12
34586830	2021	CPEB alteration and aberrant transcriptome-polyadenylation lead to a treatable SLC19A3 deficiency in Huntington's disease.	8
33162033	2021	Estrogen promotes increased breast cancer cell proliferation and migration through downregulation of CPEB1 expression.	3
33892791	2021	DNA hypermethylation contributes to colorectal cancer metastasis by regulating the binding of CEBPB and TFCP2 to the CPEB1 promoter.	12
34586830	2021	CPEB alteration and aberrant transcriptome-polyadenylation lead to a treatable SLC19A3 deficiency in Huntington's disease.	8
32113875	2020	CPEB1 or CPEB4 knockdown suppresses the TAK1 and Smad signalings in THP-1 macrophage-like cells and dermal fibroblasts.	8
32354341	2020	CPEB1 deletion is not a common explanation for premature ovarian insufficiency in a Chinese cohort.	2
32113875	2020	CPEB1 or CPEB4 knockdown suppresses the TAK1 and Smad signalings in THP-1 macrophage-like cells and dermal fibroblasts.	8
32354341	2020	CPEB1 deletion is not a common explanation for premature ovarian insufficiency in a Chinese cohort.	2
30411210	2019	CPEB1 Expression Correlates with Severity of Posttraumatic Ankle Osteoarthritis and Aggravates Catabolic Effect of IL-1β on Chondrocytes.	5
31521690	2019	Depletion of CPEB1 protects against oxidized LDL-induced endothelial apoptosis and inflammation though SIRT1/LOX-1 signalling pathway.	6
30411210	2019	CPEB1 Expression Correlates with Severity of Posttraumatic Ankle Osteoarthritis and Aggravates Catabolic Effect of IL-1β on Chondrocytes.	5
31521690	2019	Depletion of CPEB1 protects against oxidized LDL-induced endothelial apoptosis and inflammation though SIRT1/LOX-1 signalling pathway.	6
30106109	2018	miR‑454‑3p suppresses cell migration and invasion by targeting CPEB1 in human glioblastoma.	9

Citation

Dessen P

CPEB1 (cytoplasmic polyadenylation element binding protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2009-03-01

Online version: http://atlasgeneticsoncology.org/gene/50810/gene-explorer/js/lib/gene-explorer/