TPP2 (tripeptidyl peptidase 2)

2009-04-01  

Identity

HGNC
TPP2
LOCATION
13q33.1
LOCUSID
7174
ALIAS
IMD78,TPP-2,TPP-II,TPPII
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 7174
MIM: 190470
HGNC: 12016
Ensembl: ENSG00000134900

Variants:

dbSNP: 7174
ClinVar: 7174
TCGA: ENSG00000134900
COSMIC: TPP2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000134900ENST00000376052Q5VZU9
ENSG00000134900ENST00000376065P29144
ENSG00000134900ENST00000493770A0A494C0X4
ENSG00000134900ENST00000650757A0A494C1S6
ENSG00000134900ENST00000651448A0A494C1S4
ENSG00000134900ENST00000651544A0A494C0U1
ENSG00000134900ENST00000651748A0A494C159
ENSG00000134900ENST00000651921A0A494C1L2
ENSG00000134900ENST00000652033A0A494C0A3
ENSG00000134900ENST00000652308A0A494C1B8

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
354663662022Unveiling a novel serpinB2-tripeptidyl peptidase II signaling axis during senescence.0
354663662022Unveiling a novel serpinB2-tripeptidyl peptidase II signaling axis during senescence.0
335861352021Immune deficiency, autoimmune disease and intellectual disability: A pleiotropic disorder caused by biallelic variants in the TPP2 gene.3
335861352021Immune deficiency, autoimmune disease and intellectual disability: A pleiotropic disorder caused by biallelic variants in the TPP2 gene.3
254144422015Early-onset Evans syndrome, immunodeficiency, and premature immunosenescence associated with tripeptidyl-peptidase II deficiency.33
260418472015Tripeptidyl Peptidase II Mediates Levels of Nuclear Phosphorylated ERK1 and ERK2.6
261699842015Novel protein-protein interactions of TPPII, p53, and SIRT7.10
254144422015Early-onset Evans syndrome, immunodeficiency, and premature immunosenescence associated with tripeptidyl-peptidase II deficiency.33
260418472015Tripeptidyl Peptidase II Mediates Levels of Nuclear Phosphorylated ERK1 and ERK2.6
261699842015Novel protein-protein interactions of TPPII, p53, and SIRT7.10
253037912014TPPII, MYBBP1A and CDK2 form a protein-protein interaction network.1
255258762014Dual proteolytic pathways govern glycolysis and immune competence.25
253037912014TPPII, MYBBP1A and CDK2 form a protein-protein interaction network.1
255258762014Dual proteolytic pathways govern glycolysis and immune competence.25
229868082013Tripeptidyl peptidase II in human oral squamous cell carcinoma.12

Citation

Dessen P

TPP2 (tripeptidyl peptidase 2)

Atlas Genet Cytogenet Oncol Haematol. 2009-04-01

Online version: http://atlasgeneticsoncology.org/gene/50836