Identity
HGNC
LOCATION
9q22.31
LOCUSID
ALIAS
CENP-35,GRC5,JHDM1E,KDM7C
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 5253
MIM: 604351
HGNC: 8920
Ensembl: ENSG00000197724
Variants:
dbSNP: 5253
ClinVar: 5253
TCGA: ENSG00000197724
COSMIC: PHF2
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000197724 | ENST00000359246 | O75151 |
| ENSG00000197724 | ENST00000375376 | E7ET14 |
| ENSG00000197724 | ENST00000610682 | A0A087WW48 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Chromatin organization | REACTOME | R-HSA-4839726 |
| Chromatin modifying enzymes | REACTOME | R-HSA-3247509 |
| HDMs demethylate histones | REACTOME | R-HSA-3214842 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36380035 | 2023 | Circ_MBNL3 Restrains Hepatocellular Carcinoma Progression by Sponging miR-873-5p to Release PHF2. | 1 |
| 37828054 | 2023 | Palmitoylation-driven PHF2 ubiquitination remodels lipid metabolism through the SREBP1c axis in hepatocellular carcinoma. | 5 |
| 36380035 | 2023 | Circ_MBNL3 Restrains Hepatocellular Carcinoma Progression by Sponging miR-873-5p to Release PHF2. | 1 |
| 37828054 | 2023 | Palmitoylation-driven PHF2 ubiquitination remodels lipid metabolism through the SREBP1c axis in hepatocellular carcinoma. | 5 |
| 35729160 | 2022 | HIF-1α-mediated augmentation of miRNA-18b-5p facilitates proliferation and metastasis in osteosarcoma through attenuation PHF2. | 6 |
| 35729160 | 2022 | HIF-1α-mediated augmentation of miRNA-18b-5p facilitates proliferation and metastasis in osteosarcoma through attenuation PHF2. | 6 |
| 34741163 | 2021 | Genome-wide analysis of 53,400 people with irritable bowel syndrome highlights shared genetic pathways with mood and anxiety disorders. | 69 |
| 34741163 | 2021 | Genome-wide analysis of 53,400 people with irritable bowel syndrome highlights shared genetic pathways with mood and anxiety disorders. | 69 |
| 32232336 | 2020 | PHF2 regulates homology-directed DNA repair by controlling the resection of DNA double strand breaks. | 16 |
| 32232336 | 2020 | PHF2 regulates homology-directed DNA repair by controlling the resection of DNA double strand breaks. | 16 |
| 31214616 | 2019 | MiR-221 Promotes Hepatocellular Carcinoma Cells Migration via Targeting PHF2. | 20 |
| 31227231 | 2019 | HCF-1 Regulates De Novo Lipogenesis through a Nutrient-Sensitive Complex with ChREBP. | 20 |
| 31214616 | 2019 | MiR-221 Promotes Hepatocellular Carcinoma Cells Migration via Targeting PHF2. | 20 |
| 31227231 | 2019 | HCF-1 Regulates De Novo Lipogenesis through a Nutrient-Sensitive Complex with ChREBP. | 20 |
| 28994305 | 2018 | Plant homeodomain finger protein 2 as a novel IKAROS target in acute lymphoblastic leukemia. | 11 |
Citation
Dessen P
PHF2 (PHD finger protein 2)
Atlas Genet Cytogenet Oncol Haematol. 2009-04-01
Online version: http://atlasgeneticsoncology.org/gene/50847/phf2
