Identity
HGNC
LOCATION
9q33.2
LOCUSID
ALIAS
C5D,C5a,C5b,CPAMD4,ECLZB
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 727
MIM: 120900
HGNC: 1331
Ensembl: ENSG00000106804
Variants:
dbSNP: 727
ClinVar: 727
TCGA: ENSG00000106804
COSMIC: C5
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000106804 | ENST00000223642 | P01031 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA164776637 | eculizumab | Chemical | ClinicalAnnotation | associated | PD | 24521109 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38101498 | 2024 | Differential contributions of the C5b-9 and C5a/C5aR pathways to microvascular and macrovascular thrombosis in complement-mediated thrombotic microangiopathy patients. | 0 |
| 38117213 | 2024 | Association between TRAF1/C5 Gene Polymorphisms and IgA Vasculitis in Chinese Children. | 0 |
| 38795684 | 2024 | Complement decay-accelerating factor inhibits inflammation-induced myopia development. | 0 |
| 38101498 | 2024 | Differential contributions of the C5b-9 and C5a/C5aR pathways to microvascular and macrovascular thrombosis in complement-mediated thrombotic microangiopathy patients. | 0 |
| 38117213 | 2024 | Association between TRAF1/C5 Gene Polymorphisms and IgA Vasculitis in Chinese Children. | 0 |
| 38795684 | 2024 | Complement decay-accelerating factor inhibits inflammation-induced myopia development. | 0 |
| 36725909 | 2023 | Dual inhibition of complement C5 and CD14 attenuates inflammation in a cord blood model. | 1 |
| 38069385 | 2023 | A Transcriptome Array-Based Approach to Link SGLT-2 and Intrarenal Complement C5 Synthesis in Diabetic Nephropathy. | 0 |
| 36725909 | 2023 | Dual inhibition of complement C5 and CD14 attenuates inflammation in a cord blood model. | 1 |
| 38069385 | 2023 | A Transcriptome Array-Based Approach to Link SGLT-2 and Intrarenal Complement C5 Synthesis in Diabetic Nephropathy. | 0 |
| 34971753 | 2022 | Complement C5a induces the formation of neutrophil extracellular traps by myeloid-derived suppressor cells to promote metastasis. | 33 |
| 35094639 | 2022 | Pseudomonas aeruginosa adaptation in cystic fibrosis patients increases C5a levels and promotes neutrophil recruitment. | 11 |
| 35205259 | 2022 | C5 and SRGAP3 Polymorphisms Are Linked to Paediatric Allergic Asthma in the Italian Population. | 1 |
| 35433513 | 2022 | The C5a/C5aR1 Axis Contributes to the Pathogenesis of Acute Cystitis Through Enhancement of Adhesion and Colonization of Uropathogenic E. coli. | 2 |
| 35909516 | 2022 | Elevated Adipsin and Reduced C5a Levels in the Maternal Serum and Follicular Fluid During Implantation Are Associated With Successful Pregnancy in Obese Women. | 0 |
Citation
Dessen P
C5 (complement C5)
Atlas Genet Cytogenet Oncol Haematol. 2009-05-01
Online version: http://atlasgeneticsoncology.org/gene/50864/c5
