NKX2-8 (NK2 homeobox 8)

2009-05-01  

Identity

HGNC
NKX2-8
LOCATION
14q13.3
LOCUSID
26257
ALIAS
NKX2.8,NKX2H,Nkx2-9

Other Information

Locus ID:

NCBI: 26257
MIM: 603245
HGNC: 16364
Ensembl: ENSG00000136327

Variants:

dbSNP: 26257
ClinVar: 26257
TCGA: ENSG00000136327
COSMIC: NKX2-8

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000136327ENST00000258829O15522

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
356102072022Nkx2.8 promotes chemosensitivity in bladder urothelial carcinoma via transcriptional repression of MDR1.1
356102072022Nkx2.8 promotes chemosensitivity in bladder urothelial carcinoma via transcriptional repression of MDR1.1
310478582019NKX2-8 deletion-induced reprogramming of fatty acid metabolism confers chemoresistance in epithelial ovarian cancer.29
310478582019NKX2-8 deletion-induced reprogramming of fatty acid metabolism confers chemoresistance in epithelial ovarian cancer.29
293111572018Nkx2.8 Inhibits Epithelial-Mesenchymal Transition in Bladder Urothelial Carcinoma via Transcriptional Repression of Twist1.9
293111572018Nkx2.8 Inhibits Epithelial-Mesenchymal Transition in Bladder Urothelial Carcinoma via Transcriptional Repression of Twist1.9
236046372013Nkx2-8 downregulation promotes angiogenesis and activates NF-κB in esophageal cancer.26
236046372013Nkx2-8 downregulation promotes angiogenesis and activates NF-κB in esophageal cancer.26
222238472012The tumor-suppressor gene Nkx2.8 suppresses bladder cancer proliferation through upregulation of FOXO3a and inhibition of the MEK/ERK signaling pathway.24
222238472012The tumor-suppressor gene Nkx2.8 suppresses bladder cancer proliferation through upregulation of FOXO3a and inhibition of the MEK/ERK signaling pathway.24
211487472011Both gene amplification and allelic loss occur at 14q13.3 in lung cancer.22
211487472011Both gene amplification and allelic loss occur at 14q13.3 in lung cancer.22
192792072009Characterizing the developmental pathways TTF-1, NKX2-8, and PAX9 in lung cancer.29
192792072009Characterizing the developmental pathways TTF-1, NKX2-8, and PAX9 in lung cancer.29
121677062002Regulation of alpha-fetoprotein expression by Nkx2.8.15

Citation

Dessen P

NKX2-8 (NK2 homeobox 8)

Atlas Genet Cytogenet Oncol Haematol. 2009-05-01

Online version: http://atlasgeneticsoncology.org/gene/50867/gene-explorer/js/css/card-gene.css