TRIM3 (tripartite motif containing 3)

2009-05-01  

Identity

HGNC
TRIM3
LOCATION
11p15.4
LOCUSID
10612
ALIAS
BERP,HAC1,RNF22,RNF97
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10612
MIM: 605493
HGNC: 10064
Ensembl: ENSG00000110171

Variants:

dbSNP: 10612
ClinVar: 10612
TCGA: ENSG00000110171
COSMIC: TRIM3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000110171ENST00000345851O75382
ENSG00000110171ENST00000359518O75382
ENSG00000110171ENST00000525074O75382
ENSG00000110171ENST00000528227E9PMK8
ENSG00000110171ENST00000529529E9PMW5
ENSG00000110171ENST00000536344O75382
ENSG00000110171ENST00000639856A0A1W2PPI7

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Interferon SignalingREACTOMER-HSA-913531
Interferon gamma signalingREACTOMER-HSA-877300

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
379782732024TRIM3 facilitates ferroptosis in non-small cell lung cancer through promoting SLC7A11/xCT K11-linked ubiquitination and degradation.4
384117312024Advances in the antitumor mechanisms of tripartite motif-containing protein 3.0
379782732024TRIM3 facilitates ferroptosis in non-small cell lung cancer through promoting SLC7A11/xCT K11-linked ubiquitination and degradation.4
384117312024Advances in the antitumor mechanisms of tripartite motif-containing protein 3.0
334157202022Decreased expression of TRIM3 gene predicts a poor prognosis in gastric cancer.6
353176862022TRIM3 Inhibits H(2)O(2)-Induced Apoptosis in Human Lens Epithelial Cells by Decreasing p53 via Ubiquitination.0
353929252022TRIM3 facilitates estrogen signaling and modulates breast cancer cell progression.4
364817672022Divergent self-association properties of paralogous proteins TRIM2 and TRIM3 regulate their E3 ligase activity.3
334157202022Decreased expression of TRIM3 gene predicts a poor prognosis in gastric cancer.6
353176862022TRIM3 Inhibits H(2)O(2)-Induced Apoptosis in Human Lens Epithelial Cells by Decreasing p53 via Ubiquitination.0
353929252022TRIM3 facilitates estrogen signaling and modulates breast cancer cell progression.4
364817672022Divergent self-association properties of paralogous proteins TRIM2 and TRIM3 regulate their E3 ligase activity.3
332531192020TRIM3 attenuates apoptosis in Parkinson's disease via activating PI3K/AKT signal pathway.12
332531192020TRIM3 attenuates apoptosis in Parkinson's disease via activating PI3K/AKT signal pathway.12
305421192019Targeting TRIM3 deletion-induced tumor-associated lymphangiogenesis prohibits lymphatic metastasis in esophageal squamous cell carcinoma.9

Citation

Dessen P

TRIM3 (tripartite motif containing 3)

Atlas Genet Cytogenet Oncol Haematol. 2009-05-01

Online version: http://atlasgeneticsoncology.org/gene/50894