TYROBP (transmembrane immune signaling adaptor TYROBP)

2009-05-01  

Identity

HGNC
LOCATION
19q13.12
LOCUSID
ALIAS
DAP12,KARAP,PLOSL,PLOSL1

Other Information

Locus ID:

NCBI: 7305
MIM: 604142
HGNC: 12449
Ensembl: ENSG00000011600

Variants:

dbSNP: 7305
ClinVar: 7305
TCGA: ENSG00000011600
COSMIC: TYROBP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000011600ENST00000262629O43914
ENSG00000011600ENST00000424586X6RGC9
ENSG00000011600ENST00000544690O43914
ENSG00000011600ENST00000585901K7ES93
ENSG00000011600ENST00000586946K7EKK0
ENSG00000011600ENST00000587837K7EKK0
ENSG00000011600ENST00000589517O43914

Expression (GTEx)

0
500
1000
1500
2000

Pathways

PathwaySourceExternal ID
Natural killer cell mediated cytotoxicityKEGGko04650
Natural killer cell mediated cytotoxicityKEGGhsa04650
Osteoclast differentiationKEGGko04380
Osteoclast differentiationKEGGhsa04380
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellREACTOMER-HSA-198933
Innate Immune SystemREACTOMER-HSA-168249
DAP12 interactionsREACTOMER-HSA-2172127
DAP12 signalingREACTOMER-HSA-2424491
Cell-Cell communicationREACTOMER-HSA-1500931
Signal regulatory protein (SIRP) family interactionsREACTOMER-HSA-391160
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
Semaphorin interactionsREACTOMER-HSA-373755
Other semaphorin interactionsREACTOMER-HSA-416700
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
381812712024TYROBP as a molecular target in cholangiocarcinoma, renal cancer and abdominal aortic aneurysm.0
381812712024TYROBP as a molecular target in cholangiocarcinoma, renal cancer and abdominal aortic aneurysm.0
366582412023Human early-onset dementia caused by DAP12 deficiency reveals a unique signature of dysregulated microglia.12
371176332023MMP9 and TYROBP affect the survival of circulating tumor cells in clear cell renal cell carcinoma by adapting to tumor immune microenvironment.7
366582412023Human early-onset dementia caused by DAP12 deficiency reveals a unique signature of dysregulated microglia.12
371176332023MMP9 and TYROBP affect the survival of circulating tumor cells in clear cell renal cell carcinoma by adapting to tumor immune microenvironment.7
350784332022The role of SPI1-TYROBP-FCER1G network in oncogenesis and prognosis of osteosarcoma, and its association with immune infiltration.6
361811232022TYRO protein tyrosine kinase-binding protein predicts favorable overall survival in osteosarcoma and correlates with antitumor immunity.0
350784332022The role of SPI1-TYROBP-FCER1G network in oncogenesis and prognosis of osteosarcoma, and its association with immune infiltration.6
361811232022TYRO protein tyrosine kinase-binding protein predicts favorable overall survival in osteosarcoma and correlates with antitumor immunity.0
335139282021Constitutively Activated DAP12 Induces Functional Anti-Tumor Activation and Maturation of Human Monocyte-Derived DC.3
337866722021Identification of TYROBP and FCER1G as Key Genes with Prognostic Value in Clear Cell Renal Cell Carcinoma by Bioinformatics Analysis.6
341623552021Elevated TYROBP expression predicts poor prognosis and high tumor immune infiltration in patients with low-grade glioma.22
345884972021TYROBP, TLR4 and ITGAM regulated macrophages polarization and immune checkpoints expression in osteosarcoma.22
335139282021Constitutively Activated DAP12 Induces Functional Anti-Tumor Activation and Maturation of Human Monocyte-Derived DC.3

Citation

Dessen P

TYROBP (transmembrane immune signaling adaptor TYROBP)

Atlas Genet Cytogenet Oncol Haematol. 2009-05-01

Online version: http://atlasgeneticsoncology.org/gene/50904/tyrobp