SLC9A8 (solute carrier family 9 member A8)

2009-05-01  

Identity

HGNC
SLC9A8
LOCATION
20q13.13
LOCUSID
23315
ALIAS
NHE-8,NHE8
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 23315
MIM: 612730
HGNC: 20728
Ensembl: ENSG00000197818

Variants:

dbSNP: 23315
ClinVar: 23315
TCGA: ENSG00000197818
COSMIC: SLC9A8

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000197818ENST00000361573Q9Y2E8
ENSG00000197818ENST00000417961Q9Y2E8

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Transport of inorganic cations/anions and amino acids/oligopeptidesREACTOMER-HSA-425393
Sodium/Proton exchangersREACTOMER-HSA-425986

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
365838052023Downregulation of SLC9A8 Promotes Epithelial-Mesenchymal Transition and Metastasis in Colorectal Cancer Cells via the IL6-JAK1/STAT3 Signaling Pathway.2
365838052023Downregulation of SLC9A8 Promotes Epithelial-Mesenchymal Transition and Metastasis in Colorectal Cancer Cells via the IL6-JAK1/STAT3 Signaling Pathway.2
342887212021Functional characterization of the sodium/hydrogen exchanger 8 and its role in proliferation of colonic epithelial cells.6
342887212021Functional characterization of the sodium/hydrogen exchanger 8 and its role in proliferation of colonic epithelial cells.6
284768882017Loss of the Na(+)/H(+) exchanger NHE8 causes male infertility in mice by disrupting acrosome formation.22
284768882017Loss of the Na(+)/H(+) exchanger NHE8 causes male infertility in mice by disrupting acrosome formation.22
265647202016Intestinal NHE8 is highly expressed in goblet cells and its expression is subject to TNF-α regulation.8
265647202016Intestinal NHE8 is highly expressed in goblet cells and its expression is subject to TNF-α regulation.8
211716502011Organellar Na+/H+ exchangers: novel players in organelle pH regulation and their emerging functions.45
216665032011Nucleotide sequence of the Na+/H+ exchanger-8 in patients with congenital sodium diarrhea.6
211716502011Organellar Na+/H+ exchangers: novel players in organelle pH regulation and their emerging functions.45
216665032011Nucleotide sequence of the Na+/H+ exchanger-8 in patients with congenital sodium diarrhea.6
203752732010Epidermal growth factor inhibits intestinal NHE8 expression via reducing its basal transcription.14
207199632010The sodium/proton exchanger NHE8 regulates late endosomal morphology and function.26
203752732010Epidermal growth factor inhibits intestinal NHE8 expression via reducing its basal transcription.14

Citation

Dessen P

SLC9A8 (solute carrier family 9 member A8)

Atlas Genet Cytogenet Oncol Haematol. 2009-05-01

Online version: http://atlasgeneticsoncology.org/gene/50908/css/lib/tumors-explorer/js/template.js