SLC9A8 (solute carrier family 9 member A8)

2009-05-01 Affiliation

Identity

HGNC

SLC9A8

LOCATION

20q13.13

LOCUSID

23315

ALIAS

NHE-8,NHE8

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 23315
MIM: 612730
HGNC: 20728
Ensembl: ENSG00000197818

Variants:

dbSNP: 23315
ClinVar: 23315
TCGA: ENSG00000197818
COSMIC: SLC9A8

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000197818	ENST00000361573	Q9Y2E8
ENSG00000197818	ENST00000417961	Q9Y2E8

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Transmembrane transport of small molecules	REACTOME	R-HSA-382551
SLC-mediated transmembrane transport	REACTOME	R-HSA-425407
Transport of inorganic cations/anions and amino acids/oligopeptides	REACTOME	R-HSA-425393
Sodium/Proton exchangers	REACTOME	R-HSA-425986

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
36583805	2023	Downregulation of SLC9A8 Promotes Epithelial-Mesenchymal Transition and Metastasis in Colorectal Cancer Cells via the IL6-JAK1/STAT3 Signaling Pathway.	2
36583805	2023	Downregulation of SLC9A8 Promotes Epithelial-Mesenchymal Transition and Metastasis in Colorectal Cancer Cells via the IL6-JAK1/STAT3 Signaling Pathway.	2
34288721	2021	Functional characterization of the sodium/hydrogen exchanger 8 and its role in proliferation of colonic epithelial cells.	6
34288721	2021	Functional characterization of the sodium/hydrogen exchanger 8 and its role in proliferation of colonic epithelial cells.	6
28476888	2017	Loss of the Na(+)/H(+) exchanger NHE8 causes male infertility in mice by disrupting acrosome formation.	22
28476888	2017	Loss of the Na(+)/H(+) exchanger NHE8 causes male infertility in mice by disrupting acrosome formation.	22
26564720	2016	Intestinal NHE8 is highly expressed in goblet cells and its expression is subject to TNF-α regulation.	8
26564720	2016	Intestinal NHE8 is highly expressed in goblet cells and its expression is subject to TNF-α regulation.	8
21171650	2011	Organellar Na+/H+ exchangers: novel players in organelle pH regulation and their emerging functions.	45
21666503	2011	Nucleotide sequence of the Na+/H+ exchanger-8 in patients with congenital sodium diarrhea.	6
21171650	2011	Organellar Na+/H+ exchangers: novel players in organelle pH regulation and their emerging functions.	45
21666503	2011	Nucleotide sequence of the Na+/H+ exchanger-8 in patients with congenital sodium diarrhea.	6
20375273	2010	Epidermal growth factor inhibits intestinal NHE8 expression via reducing its basal transcription.	14
20719963	2010	The sodium/proton exchanger NHE8 regulates late endosomal morphology and function.	26
20375273	2010	Epidermal growth factor inhibits intestinal NHE8 expression via reducing its basal transcription.	14

Citation

Dessen P

SLC9A8 (solute carrier family 9 member A8)

Atlas Genet Cytogenet Oncol Haematol. 2009-05-01

Online version: http://atlasgeneticsoncology.org/gene/50908/meetings/case-report-explorer/favicon/manifest.json