SLC9A8 (solute carrier family 9 member A8)

2009-05-01  

Identity

HGNC
LOCATION
20q13.13
LOCUSID
ALIAS
NHE-8,NHE8
FUSION GENES

Other Information

Locus ID:

NCBI: 23315
MIM: 612730
HGNC: 20728
Ensembl: ENSG00000197818

Variants:

dbSNP: 23315
ClinVar: 23315
TCGA: ENSG00000197818
COSMIC: SLC9A8

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000197818ENST00000361573Q9Y2E8
ENSG00000197818ENST00000417961Q9Y2E8

Expression (GTEx)

0
5
10
15
20
25
30
35

Pathways

PathwaySourceExternal ID
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Transport of inorganic cations/anions and amino acids/oligopeptidesREACTOMER-HSA-425393
Sodium/Proton exchangersREACTOMER-HSA-425986

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
365838052023Downregulation of SLC9A8 Promotes Epithelial-Mesenchymal Transition and Metastasis in Colorectal Cancer Cells via the IL6-JAK1/STAT3 Signaling Pathway.2
365838052023Downregulation of SLC9A8 Promotes Epithelial-Mesenchymal Transition and Metastasis in Colorectal Cancer Cells via the IL6-JAK1/STAT3 Signaling Pathway.2
342887212021Functional characterization of the sodium/hydrogen exchanger 8 and its role in proliferation of colonic epithelial cells.6
342887212021Functional characterization of the sodium/hydrogen exchanger 8 and its role in proliferation of colonic epithelial cells.6
284768882017Loss of the Na(+)/H(+) exchanger NHE8 causes male infertility in mice by disrupting acrosome formation.22
284768882017Loss of the Na(+)/H(+) exchanger NHE8 causes male infertility in mice by disrupting acrosome formation.22
265647202016Intestinal NHE8 is highly expressed in goblet cells and its expression is subject to TNF-α regulation.8
265647202016Intestinal NHE8 is highly expressed in goblet cells and its expression is subject to TNF-α regulation.8
211716502011Organellar Na+/H+ exchangers: novel players in organelle pH regulation and their emerging functions.45
216665032011Nucleotide sequence of the Na+/H+ exchanger-8 in patients with congenital sodium diarrhea.6
211716502011Organellar Na+/H+ exchangers: novel players in organelle pH regulation and their emerging functions.45
216665032011Nucleotide sequence of the Na+/H+ exchanger-8 in patients with congenital sodium diarrhea.6
203752732010Epidermal growth factor inhibits intestinal NHE8 expression via reducing its basal transcription.14
207199632010The sodium/proton exchanger NHE8 regulates late endosomal morphology and function.26
203752732010Epidermal growth factor inhibits intestinal NHE8 expression via reducing its basal transcription.14

Citation

Dessen P

SLC9A8 (solute carrier family 9 member A8)

Atlas Genet Cytogenet Oncol Haematol. 2009-05-01

Online version: http://atlasgeneticsoncology.org/gene/50908/teaching-explorer/css/lib/favicon/manifest.json