GSDMD (gasdermin D)

2009-05-01  

Identity

HGNC
GSDMD
LOCATION
8q24.3
LOCUSID
79792
ALIAS
DF5L,DFNA5L,FKSG10,GSDMDC1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 79792
MIM: 617042
HGNC: 25697
Ensembl: ENSG00000104518

Variants:

dbSNP: 79792
ClinVar: 79792
TCGA: ENSG00000104518
COSMIC: GSDMD

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000104518ENST00000262580P57764
ENSG00000104518ENST00000525208H0YDB0
ENSG00000104518ENST00000525721E9PQ48
ENSG00000104518ENST00000526406P57764
ENSG00000104518ENST00000529854E9PRF1
ENSG00000104518ENST00000533063G3V1A6
ENSG00000104518ENST00000533348E9PQR9
ENSG00000104518ENST00000533888E9PNZ0
ENSG00000104518ENST00000534018E9PIB2

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
NOD-like receptor signaling pathwayKEGGko04621
NOD-like receptor signaling pathwayKEGGhsa04621
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
379140992024Gasdermin D activation in oligodendrocytes and microglia drives inflammatory demyelination in progressive multiple sclerosis.0
379317222024CHMP4B and VSP4A reverse GSDMD-mediated pyroptosis by cell membrane remodeling in endometrial carcinoma.2
379625782024O-GlcNAc modification of GSDMD attenuates LPS-induced endothelial cells pyroptosis.0
382427592024Gasdermin D triggers cardiolipin-driven mitochondrial damage and pyroptosis.0
382507272024GSDMD suppresses keratinocyte differentiation by inhibiting FLG expression and attenuating KCTD6-mediated HDAC1 degradation in atopic dermatitis.0
382957202024Gasdermin D regulates soluble fms-like tyrosine kinase 1 release in macrophages.0
384297622024TR4 worsen urosepsis by regulating GSDMD.0
385301582024The palmitoylation of gasdermin D directs its membrane translocation and pore formation during pyroptosis.6
385489662024Targeting STING elicits GSDMD-dependent pyroptosis and boosts anti-tumor immunity in renal cell carcinoma.0
385992392024ROS-dependent S-palmitoylation activates cleaved and intact gasdermin D.2
386174502024Silent information regulator sirtuin 1 ameliorates acute liver failure via the p53/glutathione peroxidase 4/gasdermin D axis.2
388314512024Gasdermin D deficiency aborts myeloid calcium influx to drive granulopoiesis in lupus nephritis.0
389935662024P2X7R Modulates NEK7-NLRP3 Interaction to Exacerbate Experimental Autoimmune Prostatitis via GSDMD-mediated Prostate Epithelial Cell Pyroptosis.0
379140992024Gasdermin D activation in oligodendrocytes and microglia drives inflammatory demyelination in progressive multiple sclerosis.0
379317222024CHMP4B and VSP4A reverse GSDMD-mediated pyroptosis by cell membrane remodeling in endometrial carcinoma.2

Citation

Dessen P

GSDMD (gasdermin D)

Atlas Genet Cytogenet Oncol Haematol. 2009-05-01

Online version: http://atlasgeneticsoncology.org/gene/50915