Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 64078
MIM: 608269
HGNC: 16484
Ensembl: ENSG00000197506
Variants:
dbSNP: 64078
ClinVar: 64078
TCGA: ENSG00000197506
COSMIC: SLC28A3
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000197506 | ENST00000376238 | Q9HAS3 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA130620651 | anthracyclines and related substances | Chemical | ClinicalAnnotation | associated | PD | 21900104, 23441093 | |
| PA445062 | Neoplasms | Disease | ClinicalAnnotation | associated | PK | PD | 21900104, 23441093, 24300978 |
| PA449212 | daunorubicin | Chemical | GuidelineAnnotation | associated | |||
| PA449412 | doxorubicin | Chemical | GuidelineAnnotation | associated | |||
| PA449748 | gemcitabine | Chemical | ClinicalAnnotation, Pathway | associated | PK | 24300978, 25162786 | |
| PA451954 | zidovudine | Chemical | Pathway | associated | 22960662 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37828659 | 2024 | The Role of RARG rs2229774, SLC28A3 rs7853758, and UGT1A6*4 rs17863783 Single-nucleotide Polymorphisms in the Doxorubicin-induced Cardiotoxicity in Solid Childhood Tumors. | 0 |
| 37828659 | 2024 | The Role of RARG rs2229774, SLC28A3 rs7853758, and UGT1A6*4 rs17863783 Single-nucleotide Polymorphisms in the Doxorubicin-induced Cardiotoxicity in Solid Childhood Tumors. | 0 |
| 33910126 | 2021 | Characterization of deoxyribonucleoside transport mediated by concentrative nucleoside transporters. | 5 |
| 33974709 | 2021 | Gene-Gene Interactions of Gemcitabine Metabolizing-Enzyme Genes hCNT3 and WEE1 for Preventing Severe Gemcitabine-Induced Hematological Toxicity. | 0 |
| 34751688 | 2021 | Allosteric and transport modulation of human concentrative nucleoside transporter 3 at the atomic scale. | 2 |
| 33910126 | 2021 | Characterization of deoxyribonucleoside transport mediated by concentrative nucleoside transporters. | 5 |
| 33974709 | 2021 | Gene-Gene Interactions of Gemcitabine Metabolizing-Enzyme Genes hCNT3 and WEE1 for Preventing Severe Gemcitabine-Induced Hematological Toxicity. | 0 |
| 34751688 | 2021 | Allosteric and transport modulation of human concentrative nucleoside transporter 3 at the atomic scale. | 2 |
| 30778771 | 2020 | Association of SLC28A3 Gene Expression and CYP2B6*6 Allele with the Response to Fludarabine Plus Cyclophosphamide in Chronic Lymphocytic Leukemia Patients. | 3 |
| 32776918 | 2020 | Cryo-EM structure of the human concentrative nucleoside transporter CNT3. | 9 |
| 30778771 | 2020 | Association of SLC28A3 Gene Expression and CYP2B6*6 Allele with the Response to Fludarabine Plus Cyclophosphamide in Chronic Lymphocytic Leukemia Patients. | 3 |
| 32776918 | 2020 | Cryo-EM structure of the human concentrative nucleoside transporter CNT3. | 9 |
| 30096006 | 2018 | Inward- and outward-facing homology modeling of human concentrative nucleoside transporter 3 (hCNT3) predicts an elevator-type transport mechanism. | 2 |
| 30096006 | 2018 | Inward- and outward-facing homology modeling of human concentrative nucleoside transporter 3 (hCNT3) predicts an elevator-type transport mechanism. | 2 |
| 28385889 | 2017 | Substituted cysteine accessibility method (SCAM) analysis of the transport domain of human concentrative nucleoside transporter 3 (hCNT3) and other family members reveals features of structural and functional importance. | 7 |
Citation
Dessen P
SLC28A3 (solute carrier family 28 member 3)
Atlas Genet Cytogenet Oncol Haematol. 2009-06-01
Online version: http://atlasgeneticsoncology.org/gene/50956/slc28a3
