FLNB (filamin B)

2009-06-01  

Identity

HGNC
LOCATION
3p14.3
LOCUSID
ALIAS
ABP-278,ABP-280,AOI,FH1,FLN-B,FLN1L,LRS1,SCT,TABP,TAP
FUSION GENES

Other Information

Locus ID:

NCBI: 2317
MIM: 603381
HGNC: 3755
Ensembl: ENSG00000136068

Variants:

dbSNP: 2317
ClinVar: 2317
TCGA: ENSG00000136068
COSMIC: FLNB

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000136068ENST00000295956O75369
ENSG00000136068ENST00000358537O75369
ENSG00000136068ENST00000419752A0A0A0MT44
ENSG00000136068ENST00000429972O75369
ENSG00000136068ENST00000466455H7C5L4
ENSG00000136068ENST00000470231A0A0C4DGA1
ENSG00000136068ENST00000490882O75369
ENSG00000136068ENST00000493452E7EN95

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
MAPK signaling pathwayKEGGko04010
Focal adhesionKEGGko04510
MAPK signaling pathwayKEGGhsa04010
Focal adhesionKEGGhsa04510
Salmonella infectionKEGGko05132
Salmonella infectionKEGGhsa05132
Proteoglycans in cancerKEGGhsa05205
Proteoglycans in cancerKEGGko05205
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Interferon SignalingREACTOMER-HSA-913531
Antiviral mechanism by IFN-stimulated genesREACTOMER-HSA-1169410
ISG15 antiviral mechanismREACTOMER-HSA-1169408

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
383160822024Effect of disulfidptosis-related genes SLC3A2, SLC7A11 and FLNB polymorphisms on risk of autoimmune thyroiditis in a Chinese population.0
384120442024Filamin B restricts vaccinia virus spread and is targeted by vaccinia virus protein C4.0
387438672024A novel variant in the FLNB gene associated with spondylocarpotarsal synostosis syndrome.0
388801872024ETS homologous factor, controlled by lysine-specific demethylase 5B, suppresses clear cell renal cell carcinoma by inducing Filamin-B.0
383160822024Effect of disulfidptosis-related genes SLC3A2, SLC7A11 and FLNB polymorphisms on risk of autoimmune thyroiditis in a Chinese population.0
384120442024Filamin B restricts vaccinia virus spread and is targeted by vaccinia virus protein C4.0
387438672024A novel variant in the FLNB gene associated with spondylocarpotarsal synostosis syndrome.0
388801872024ETS homologous factor, controlled by lysine-specific demethylase 5B, suppresses clear cell renal cell carcinoma by inducing Filamin-B.0
372208552023Actin-binding protein filamin B regulates the cell-surface retention of endothelial sphingosine 1-phosphate receptor 1.0
372208552023Actin-binding protein filamin B regulates the cell-surface retention of endothelial sphingosine 1-phosphate receptor 1.0
344919192022Whole Exome Sequencing in Individuals with Idiopathic Clubfoot Reveals a Recurrent Filamin B (FLNB) Deletion.3
358324912022Cell-Dependent Pathogenic Roles of Filamin B in Different Skeletal Malformations.2
344919192022Whole Exome Sequencing in Individuals with Idiopathic Clubfoot Reveals a Recurrent Filamin B (FLNB) Deletion.3
358324912022Cell-Dependent Pathogenic Roles of Filamin B in Different Skeletal Malformations.2
336495192021The variants at FLNA and FLNB contribute to the susceptibility of hypertension and stroke with differentially expressed mRNA.4

Citation

Dessen P

FLNB (filamin B)

Atlas Genet Cytogenet Oncol Haematol. 2009-06-01

Online version: http://atlasgeneticsoncology.org/gene/50959/gene-fusions-explorer/haematological-explorer/cancer-prone-explorer/