FLNB (filamin B)

2009-06-01  

Identity

HGNC
FLNB
LOCATION
3p14.3
LOCUSID
2317
ALIAS
ABP-278,ABP-280,AOI,FH1,FLN-B,FLN1L,LRS1,SCT,TABP,TAP
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 2317
MIM: 603381
HGNC: 3755
Ensembl: ENSG00000136068

Variants:

dbSNP: 2317
ClinVar: 2317
TCGA: ENSG00000136068
COSMIC: FLNB

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000136068ENST00000295956O75369
ENSG00000136068ENST00000358537O75369
ENSG00000136068ENST00000419752A0A0A0MT44
ENSG00000136068ENST00000429972O75369
ENSG00000136068ENST00000466455H7C5L4
ENSG00000136068ENST00000470231A0A0C4DGA1
ENSG00000136068ENST00000490882O75369
ENSG00000136068ENST00000493452E7EN95

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MAPK signaling pathwayKEGGko04010
Focal adhesionKEGGko04510
MAPK signaling pathwayKEGGhsa04010
Focal adhesionKEGGhsa04510
Salmonella infectionKEGGko05132
Salmonella infectionKEGGhsa05132
Proteoglycans in cancerKEGGhsa05205
Proteoglycans in cancerKEGGko05205
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Interferon SignalingREACTOMER-HSA-913531
Antiviral mechanism by IFN-stimulated genesREACTOMER-HSA-1169410
ISG15 antiviral mechanismREACTOMER-HSA-1169408

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
383160822024Effect of disulfidptosis-related genes SLC3A2, SLC7A11 and FLNB polymorphisms on risk of autoimmune thyroiditis in a Chinese population.0
384120442024Filamin B restricts vaccinia virus spread and is targeted by vaccinia virus protein C4.0
387438672024A novel variant in the FLNB gene associated with spondylocarpotarsal synostosis syndrome.0
388801872024ETS homologous factor, controlled by lysine-specific demethylase 5B, suppresses clear cell renal cell carcinoma by inducing Filamin-B.0
383160822024Effect of disulfidptosis-related genes SLC3A2, SLC7A11 and FLNB polymorphisms on risk of autoimmune thyroiditis in a Chinese population.0
384120442024Filamin B restricts vaccinia virus spread and is targeted by vaccinia virus protein C4.0
387438672024A novel variant in the FLNB gene associated with spondylocarpotarsal synostosis syndrome.0
388801872024ETS homologous factor, controlled by lysine-specific demethylase 5B, suppresses clear cell renal cell carcinoma by inducing Filamin-B.0
372208552023Actin-binding protein filamin B regulates the cell-surface retention of endothelial sphingosine 1-phosphate receptor 1.0
372208552023Actin-binding protein filamin B regulates the cell-surface retention of endothelial sphingosine 1-phosphate receptor 1.0
344919192022Whole Exome Sequencing in Individuals with Idiopathic Clubfoot Reveals a Recurrent Filamin B (FLNB) Deletion.3
358324912022Cell-Dependent Pathogenic Roles of Filamin B in Different Skeletal Malformations.2
344919192022Whole Exome Sequencing in Individuals with Idiopathic Clubfoot Reveals a Recurrent Filamin B (FLNB) Deletion.3
358324912022Cell-Dependent Pathogenic Roles of Filamin B in Different Skeletal Malformations.2
336495192021The variants at FLNA and FLNB contribute to the susceptibility of hypertension and stroke with differentially expressed mRNA.4

Citation

Dessen P

FLNB (filamin B)

Atlas Genet Cytogenet Oncol Haematol. 2009-06-01

Online version: http://atlasgeneticsoncology.org/gene/50959/gene-fusions-explorer/haematological-explorer/css/card-gene.css