Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 55170
MIM: 608274
HGNC: 18241
Ensembl: ENSG00000198890
Variants:
dbSNP: 55170
ClinVar: 55170
TCGA: ENSG00000198890
COSMIC: PRMT6
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000198890 | ENST00000370078 | Q96LA8 |
| ENSG00000198890 | ENST00000650338 | A0A3B3ITK4 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Chromatin organization | REACTOME | R-HSA-4839726 |
| Chromatin modifying enzymes | REACTOME | R-HSA-3247509 |
| RMTs methylate histone arginines | REACTOME | R-HSA-3214858 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38842205 | 2024 | PRMT6 Promotes the Immune Evasion of Gastric Cancer by Upregulating ANXA1. | 0 |
| 38842205 | 2024 | PRMT6 Promotes the Immune Evasion of Gastric Cancer by Upregulating ANXA1. | 0 |
| 36191854 | 2023 | Arginine Methylation of Integrin Alpha-4 Prevents Fibrosis Development in Alcohol-Associated Liver Disease. | 6 |
| 36400182 | 2023 | PRMT6 functionally associates with PRMT5 to promote colorectal cancer progression through epigenetically repressing the expression of CDKN2B and CCNG1. | 3 |
| 36792756 | 2023 | PRMT6-CDC20 facilitates glioblastoma progression via the degradation of CDKN1B. | 5 |
| 36814156 | 2023 | MiR-141-3p promotes malignant progression in prostate cancer through AlkB homolog 5-mediated m(6)A modification of protein arginine methyltransferase 6. | 4 |
| 37813837 | 2023 | PRMT6 methylation of STAT3 regulates tumor metastasis in breast cancer. | 10 |
| 36191854 | 2023 | Arginine Methylation of Integrin Alpha-4 Prevents Fibrosis Development in Alcohol-Associated Liver Disease. | 6 |
| 36400182 | 2023 | PRMT6 functionally associates with PRMT5 to promote colorectal cancer progression through epigenetically repressing the expression of CDKN2B and CCNG1. | 3 |
| 36792756 | 2023 | PRMT6-CDC20 facilitates glioblastoma progression via the degradation of CDKN1B. | 5 |
| 36814156 | 2023 | MiR-141-3p promotes malignant progression in prostate cancer through AlkB homolog 5-mediated m(6)A modification of protein arginine methyltransferase 6. | 4 |
| 37813837 | 2023 | PRMT6 methylation of STAT3 regulates tumor metastasis in breast cancer. | 10 |
| 33186656 | 2021 | PRMT6 deficiency induces autophagy in hostile microenvironments of hepatocellular carcinoma tumors by regulating BAG5-associated HSC70 stability. | 12 |
| 33539787 | 2021 | PRMT6 methylation of RCC1 regulates mitosis, tumorigenicity, and radiation response of glioblastoma stem cells. | 44 |
| 33764612 | 2021 | Systematic investigation of PRMT6 substrate recognition reveals broad specificity with a preference for an RG motif or basic and bulky residues. | 6 |
Citation
Dessen P
PRMT6 (protein arginine methyltransferase 6)
Atlas Genet Cytogenet Oncol Haematol. 2009-06-01
Online version: http://atlasgeneticsoncology.org/gene/50961/prmt6
