ME2 (malic enzyme 2)

2009-06-01  

Identity

HGNC
ME2
LOCATION
18q21.2
LOCUSID
4200
ALIAS
ODS1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 4200
MIM: 154270
HGNC: 6984
Ensembl: ENSG00000082212

Variants:

dbSNP: 4200
ClinVar: 4200
TCGA: ENSG00000082212
COSMIC: ME2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000082212ENST00000321341P23368
ENSG00000082212ENST00000382927P23368
ENSG00000082212ENST00000585680A0A1W2PPY2
ENSG00000082212ENST00000638410A0A1W2PQT3
ENSG00000082212ENST00000638937A0A1W2PQY8
ENSG00000082212ENST00000639115A0A1W2PRY9
ENSG00000082212ENST00000639255A0A1W2PR68
ENSG00000082212ENST00000639398A0A1W2PRH1
ENSG00000082212ENST00000639612A0A1W2PRS2
ENSG00000082212ENST00000639665A0A1W2PQ37
ENSG00000082212ENST00000639688A0A1W2PRY9
ENSG00000082212ENST00000639850A0A1W2PPH1
ENSG00000082212ENST00000640530A0A1W2PQH4
ENSG00000082212ENST00000640965A0A1W2PQH3
ENSG00000082212ENST00000640967A0A1W2PQF8

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Pyruvate metabolismKEGGko00620
Pyruvate metabolismKEGGhsa00620
Carbon metabolismKEGGhsa01200
Carbon metabolismKEGGko01200

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
380075512024SIRT5-mediated ME2 desuccinylation promotes cancer growth by enhancing mitochondrial respiration.1
380075512024SIRT5-mediated ME2 desuccinylation promotes cancer growth by enhancing mitochondrial respiration.1
352287432022Malic enzyme 2 maintains protein stability of mutant p53 through 2-hydroxyglutarate.15
352287432022Malic enzyme 2 maintains protein stability of mutant p53 through 2-hydroxyglutarate.15
325644852020Expression levels of SIX1, ME2, and AP2M1 in adenoid cystic carcinoma and mucoepidermoid carcinoma.6
325644852020Expression levels of SIX1, ME2, and AP2M1 in adenoid cystic carcinoma and mucoepidermoid carcinoma.6
307197162019Replication, reanalysis, and gene expression: ME2 and genetic generalized epilepsy.6
307197162019Replication, reanalysis, and gene expression: ME2 and genetic generalized epilepsy.6
280994192017Genomic deletion of malic enzyme 2 confers collateral lethality in pancreatic cancer.127
281741722017Collateral Lethality in Pancreatic Cancer.0
280994192017Genomic deletion of malic enzyme 2 confers collateral lethality in pancreatic cancer.127
281741722017Collateral Lethality in Pancreatic Cancer.0
263811162016Expression of Malic Enzymes in Sebaceous Lesions.1
271661882016The mechanisms of malic enzyme 2 in the tumorigenesis of human gliomas.15
263811162016Expression of Malic Enzymes in Sebaceous Lesions.1

Citation

Dessen P

ME2 (malic enzyme 2)

Atlas Genet Cytogenet Oncol Haematol. 2009-06-01

Online version: http://atlasgeneticsoncology.org/gene/50969