CALCRL (calcitonin receptor like receptor)

2009-06-01  

Identity

HGNC
LOCATION
2q32.1
LOCUSID
ALIAS
CGRPR,CRLR,LMPHM8
FUSION GENES

Other Information

Locus ID:

NCBI: 10203
MIM: 114190
HGNC: 16709
Ensembl: ENSG00000064989

Variants:

dbSNP: 10203
ClinVar: 10203
TCGA: ENSG00000064989
COSMIC: CALCRL

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000064989ENST00000392370Q16602
ENSG00000064989ENST00000409998Q16602
ENSG00000064989ENST00000410068Q16602
ENSG00000064989ENST00000410102B8ZZJ4
ENSG00000064989ENST00000447403E7EN01

Expression (GTEx)

0
10
20
30
40
50
60
70

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Neuroactive ligand-receptor interactionKEGGhsa04080
Vascular smooth muscle contractionKEGGhsa04270
Vascular smooth muscle contractionKEGGko04270
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class B/2 (Secretin family receptors)REACTOMER-HSA-373080
Calcitonin-like ligand receptorsREACTOMER-HSA-419812
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (s) signalling eventsREACTOMER-HSA-418555

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
379483182024CALCRL induces resistance to daunorubicin in acute myeloid leukemia cells through upregulation of XRCC5/TYK2/JAK1 pathway.0
383492602024CALCRL knockdown suppresses cancer stemness and chemoresistance in acute myeloid leukemia with FLT3-ITD and DNM3TA-R882 double mutations.0
386021032024Coronary Artery Disease Risk Variant Dampens the Expression of CALCRL by Reducing HSF Binding to Shear Stress Responsive Enhancer in Endothelial Cells In Vitro.0
379483182024CALCRL induces resistance to daunorubicin in acute myeloid leukemia cells through upregulation of XRCC5/TYK2/JAK1 pathway.0
383492602024CALCRL knockdown suppresses cancer stemness and chemoresistance in acute myeloid leukemia with FLT3-ITD and DNM3TA-R882 double mutations.0
386021032024Coronary Artery Disease Risk Variant Dampens the Expression of CALCRL by Reducing HSF Binding to Shear Stress Responsive Enhancer in Endothelial Cells In Vitro.0
346557172022Identification and validation of CALCRL-associated prognostic genes in acute myeloid leukemia.5
346557172022Identification and validation of CALCRL-associated prognostic genes in acute myeloid leukemia.5
334136302021Short tandem repeat near hypoxia response element (HRE) instead of HRE genetic variants in promoter calcitonin receptor-like receptor (CRLR) gene as risk factor in severe preeclampsia: a preliminary study.1
334622362021Adrenomedullin-CALCRL axis controls relapse-initiating drug tolerant acute myeloid leukemia cells.24
336028642021Structure and dynamics of the CGRP receptor in apo and peptide-bound forms.41
334136302021Short tandem repeat near hypoxia response element (HRE) instead of HRE genetic variants in promoter calcitonin receptor-like receptor (CRLR) gene as risk factor in severe preeclampsia: a preliminary study.1
334622362021Adrenomedullin-CALCRL axis controls relapse-initiating drug tolerant acute myeloid leukemia cells.24
336028642021Structure and dynamics of the CGRP receptor in apo and peptide-bound forms.41
316424912020Altered Expression of Adrenomedullin 2 and its Receptor in the Adipose Tissue of Obese Patients.5

Citation

Dessen P

CALCRL (calcitonin receptor like receptor)

Atlas Genet Cytogenet Oncol Haematol. 2009-06-01

Online version: http://atlasgeneticsoncology.org/gene/50973/calcrl