USP16 (ubiquitin specific peptidase 16)

2009-08-01  

Identity

HGNC
USP16
LOCATION
21q21.3
LOCUSID
10600
ALIAS
UBP-M,UBPM
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10600
MIM: 604735
HGNC: 12614
Ensembl: ENSG00000156256

Variants:

dbSNP: 10600
ClinVar: 10600
TCGA: ENSG00000156256
COSMIC: USP16

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000156256ENST00000334352Q9Y5T5
ENSG00000156256ENST00000399973H9KVB6
ENSG00000156256ENST00000399975Q9Y5T5
ENSG00000156256ENST00000399976Q9Y5T5

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
DeubiquitinationREACTOMER-HSA-5688426
Ub-specific processing proteasesREACTOMER-HSA-5689880

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
384621642024O-GlcNAcylation stimulates the deubiquitination activity of USP16 and regulates cell cycle progression.0
384621642024O-GlcNAcylation stimulates the deubiquitination activity of USP16 and regulates cell cycle progression.0
359530002022LncRNA MNX1-AS1 sustains inactivation of Hippo pathway through a positive feedback loop with USP16/IGF2BP3 axis in gallbladder cancer.11
359530002022LncRNA MNX1-AS1 sustains inactivation of Hippo pathway through a positive feedback loop with USP16/IGF2BP3 axis in gallbladder cancer.11
335467262021USP16 regulates castration-resistant prostate cancer cell proliferation by deubiquitinating and stablizing c-Myc.25
335467262021USP16 regulates castration-resistant prostate cancer cell proliferation by deubiquitinating and stablizing c-Myc.25
321297642020USP16 counteracts mono-ubiquitination of RPS27a and promotes maturation of the 40S ribosomal subunit.20
329991902020USP16 Regulates the Stability and Function of LDL receptor by Deubiquitination.3
321297642020USP16 counteracts mono-ubiquitination of RPS27a and promotes maturation of the 40S ribosomal subunit.20
329991902020USP16 Regulates the Stability and Function of LDL receptor by Deubiquitination.3
311353812019USP16-mediated deubiquitination of calcineurin A controls peripheral T cell maintenance.25
318887152019Transcriptional activation of USP16 gene expression by NFκB signaling.5
311353812019USP16-mediated deubiquitination of calcineurin A controls peripheral T cell maintenance.25
318887152019Transcriptional activation of USP16 gene expression by NFκB signaling.5
275864452016An Integrated Human/Murine Transcriptome and Pathway Approach To Identify Prenatal Treatments For Down Syndrome.32

Citation

Dessen P

USP16 (ubiquitin specific peptidase 16)

Atlas Genet Cytogenet Oncol Haematol. 2009-08-01

Online version: http://atlasgeneticsoncology.org/gene/51008/teaching-explorer/cancer-prone-explorer/favicon/apple-touch-icon.png