ASRGL1 (asparaginase and isoaspartyl peptidase 1)

2009-08-01  

Identity

HGNC
ASRGL1
LOCATION
11q12.3
LOCUSID
80150
ALIAS
ALP,ALP1,CRASH
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 80150
MIM: 609212
HGNC: 16448
Ensembl: ENSG00000162174

Variants:

dbSNP: 80150
ClinVar: 80150
TCGA: ENSG00000162174
COSMIC: ASRGL1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000162174ENST00000301776Q7L266
ENSG00000162174ENST00000301776A0A024R573
ENSG00000162174ENST00000415229Q7L266
ENSG00000162174ENST00000415229A0A024R573
ENSG00000162174ENST00000526096A0A087WZI5
ENSG00000162174ENST00000528206A0A087X1T8
ENSG00000162174ENST00000529226E9PJK6
ENSG00000162174ENST00000534183E9PJK6
ENSG00000162174ENST00000534571A0A087WUG3
ENSG00000162174ENST00000628829E9PJK6

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Phenylalanine and tyrosine catabolismREACTOMER-HSA-71182
Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolismREACTOMER-HSA-6788656

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
365725702023ASRGL1 downregulation suppresses hepatocellular carcinoma tumorigenesis in a CDK1-dependent manner.0
368423232023l-Asparaginase regulates mTORC1 activity via a TSC2-dependent pathway in pancreatic beta cells.1
365725702023ASRGL1 downregulation suppresses hepatocellular carcinoma tumorigenesis in a CDK1-dependent manner.0
368423232023l-Asparaginase regulates mTORC1 activity via a TSC2-dependent pathway in pancreatic beta cells.1
324340382020The role of the quaternary structure in the activation of human L-asparaginase.3
324340382020The role of the quaternary structure in the activation of human L-asparaginase.3
290968822018Asparaginase-like protein 1 is an independent prognostic marker in primary endometrial cancer, and is frequently lost in metastatic lesions.8
294869922018Combined ASRGL1 and p53 immunohistochemistry as an independent predictor of survival in endometrioid endometrial carcinoma.9
296846832018Brain-related proteins as potential CSF biomarkers of Alzheimer's disease: A targeted mass spectrometry approach.38
297672602018RNAi‑mediated downregulation of asparaginase‑like protein 1 inhibits growth and promotes apoptosis of human cervical cancer line SiHa.4
290968822018Asparaginase-like protein 1 is an independent prognostic marker in primary endometrial cancer, and is frequently lost in metastatic lesions.8
294869922018Combined ASRGL1 and p53 immunohistochemistry as an independent predictor of survival in endometrioid endometrial carcinoma.9
296846832018Brain-related proteins as potential CSF biomarkers of Alzheimer's disease: A targeted mass spectrometry approach.38
297672602018RNAi‑mediated downregulation of asparaginase‑like protein 1 inhibits growth and promotes apoptosis of human cervical cancer line SiHa.4
267806882016Intramolecular Cleavage of the hASRGL1 Homodimer Occurs in Two Stages.7

Citation

Dessen P

ASRGL1 (asparaginase and isoaspartyl peptidase 1)

Atlas Genet Cytogenet Oncol Haematol. 2009-08-01

Online version: http://atlasgeneticsoncology.org/gene/51011/teaching-explorer/js/_common.js