Identity
HGNC
LOCATION
1q44
LOCUSID
ALIAS
C1orf121,CGI-146,DESI,DESI1,DeSI-2,FAM152A,PNAS-4,PPPDE1
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 51029
MIM: 614638
HGNC: 24264
Ensembl: ENSG00000121644
Variants:
dbSNP: 51029
ClinVar: 51029
TCGA: ENSG00000121644
COSMIC: DESI2
RNA/Proteins
Expression (GTEx)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 30411297 | 2019 | Desumoylating Isopeptidase 2 (DESI2) Inhibits Proliferation and Promotes Apoptosis of Pancreatic Cancer Cells through Regulating PI3K/AKT/mTOR Signaling Pathway. | 2 |
| 30426280 | 2019 | PPPDE1 promotes hepatocellular carcinoma development by negatively regulate p53 and apoptosis. | 7 |
| 30411297 | 2019 | Desumoylating Isopeptidase 2 (DESI2) Inhibits Proliferation and Promotes Apoptosis of Pancreatic Cancer Cells through Regulating PI3K/AKT/mTOR Signaling Pathway. | 2 |
| 30426280 | 2019 | PPPDE1 promotes hepatocellular carcinoma development by negatively regulate p53 and apoptosis. | 7 |
| 30055135 | 2018 | Combination of DESI2 and endostatin gene therapy significantly improves antitumor efficacy by accumulating DNA lesions, inducing apoptosis and inhibiting angiogenesis. | 3 |
| 30055135 | 2018 | Combination of DESI2 and endostatin gene therapy significantly improves antitumor efficacy by accumulating DNA lesions, inducing apoptosis and inhibiting angiogenesis. | 3 |
| 28483520 | 2017 | PPPDE1 is a novel deubiquitinase belonging to a cysteine isopeptidase family. | 10 |
| 28483520 | 2017 | PPPDE1 is a novel deubiquitinase belonging to a cysteine isopeptidase family. | 10 |
| 25079376 | 2015 | High Phosphorylation Status of AKT/mTOR Signal in DESI2-Reduced Pancreatic Ductal Adenocarcinoma. | 2 |
| 25918161 | 2015 | PNAS-4, an Early DNA Damage Response Gene, Induces S Phase Arrest and Apoptosis by Activating Checkpoint Kinases in Lung Cancer Cells. | 12 |
| 25079376 | 2015 | High Phosphorylation Status of AKT/mTOR Signal in DESI2-Reduced Pancreatic Ductal Adenocarcinoma. | 2 |
| 25918161 | 2015 | PNAS-4, an Early DNA Damage Response Gene, Induces S Phase Arrest and Apoptosis by Activating Checkpoint Kinases in Lung Cancer Cells. | 12 |
| 23322088 | 2013 | hPNAS-4 inhibits proliferation through S phase arrest and apoptosis: underlying action mechanism in ovarian cancer cells. | 6 |
| 23322088 | 2013 | hPNAS-4 inhibits proliferation through S phase arrest and apoptosis: underlying action mechanism in ovarian cancer cells. | 6 |
| 21556770 | 2012 | PNAS-4 expression and its relationship to p53 in colorectal cancer. | 1 |
Citation
Dessen P
DESI2 (desumoylating isopeptidase 2)
Atlas Genet Cytogenet Oncol Haematol. 2009-08-01
Online version: http://atlasgeneticsoncology.org/gene/51034/desi2
