PROZ (protein Z, vitamin K dependent plasma glycoprotein)

2009-08-01  

Identity

HGNC
PROZ
LOCATION
13q34
LOCUSID
8858
ALIAS
PZ

Other Information

Locus ID:

NCBI: 8858
MIM: 176895
HGNC: 9460
Ensembl: ENSG00000126231

Variants:

dbSNP: 8858
ClinVar: 8858
TCGA: ENSG00000126231
COSMIC: PROZ

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000126231ENST00000342783P22891
ENSG00000126231ENST00000375547P22891

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Gamma carboxylation, hypusine formation and arylsulfatase activationREACTOMER-HSA-163841
Gamma-carboxylation, transport, and amino-terminal cleavage of proteinsREACTOMER-HSA-159854
Gamma-carboxylation of protein precursorsREACTOMER-HSA-159740
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatusREACTOMER-HSA-159763
Removal of aminoterminal propeptides from gamma-carboxylated proteinsREACTOMER-HSA-159782

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA28660GGCXGenePathwayassociated

References

Pubmed IDYearTitleCitations
341341692022The Proteolytic Inactivation of Protein Z-Dependent Protease Inhibitor by Neutrophil Elastase Might Promote the Procoagulant Activity of Neutrophil Extracellular Traps in Sepsis.2
350722422022Expression and diagnostic value of plasma protein Z and protein Z-dependent protease inhibitor in fetal growth restriction.1
341341692022The Proteolytic Inactivation of Protein Z-Dependent Protease Inhibitor by Neutrophil Elastase Might Promote the Procoagulant Activity of Neutrophil Extracellular Traps in Sepsis.2
350722422022Expression and diagnostic value of plasma protein Z and protein Z-dependent protease inhibitor in fetal growth restriction.1
340740952021Association of Protein Z with Prediabetes and Type 2 Diabetes.5
340740952021Association of Protein Z with Prediabetes and Type 2 Diabetes.5
316253762019The Relationship between Z-Protein Level and other Parameters in Pregnant Women with Intrauterine Growth Retardation in Third Trimester.0
316253762019The Relationship between Z-Protein Level and other Parameters in Pregnant Women with Intrauterine Growth Retardation in Third Trimester.0
293601772018Low plasma protein Z levels are associated with an increased risk for perioperative bleedings.1
293639962018Polymorphisms of F2, PROC, PROZ, and F13A1 Genes are Associated With Recurrent Spontaneous Abortion in Chinese Han Women.4
296843422018The relation between protein Z polymorphism and the risk of thrombosis in Egyptian patients with antiphospholipid syndrome.2
293601772018Low plasma protein Z levels are associated with an increased risk for perioperative bleedings.1
293639962018Polymorphisms of F2, PROC, PROZ, and F13A1 Genes are Associated With Recurrent Spontaneous Abortion in Chinese Han Women.4
296843422018The relation between protein Z polymorphism and the risk of thrombosis in Egyptian patients with antiphospholipid syndrome.2
276837562017Circulating protein Z concentration, PROZ variants, and unexplained cerebral infarction in young and middle-aged adults.2

Citation

Dessen P

PROZ (protein Z, vitamin K dependent plasma glycoprotein)

Atlas Genet Cytogenet Oncol Haematol. 2009-08-01

Online version: http://atlasgeneticsoncology.org/gene/51035