CRYM (crystallin mu)

2009-08-01  

Identity

HGNC
CRYM
LOCATION
16p12.2
LOCUSID
1428
ALIAS
DFNA40,THBP
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 1428
MIM: 123740
HGNC: 2418
Ensembl: ENSG00000103316

Variants:

dbSNP: 1428
ClinVar: 1428
TCGA: ENSG00000103316
COSMIC: CRYM

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000103316ENST00000219599Q14894
ENSG00000103316ENST00000543948Q14894
ENSG00000103316ENST00000570401I3L3Y1
ENSG00000103316ENST00000571358I3L3J9
ENSG00000103316ENST00000572914I3NI53
ENSG00000103316ENST00000574448I3L2W5
ENSG00000103316ENST00000576703I3L325

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Lysine catabolismREACTOMER-HSA-71064
Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolismREACTOMER-HSA-6788656

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 2
adipose tissue
skin 1
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
384010232024Gene expression patterns of CRYM and SIGLEC10 in Alzheimer's disease: potential early diagnostic indicators.0
384188852024Crym-positive striatal astrocytes gate perseverative behaviour.2
384010232024Gene expression patterns of CRYM and SIGLEC10 in Alzheimer's disease: potential early diagnostic indicators.0
384188852024Crym-positive striatal astrocytes gate perseverative behaviour.2
330340502021Thyroid and androgen receptor signaling are antagonized by μ-Crystallin in prostate cancer.10
330340502021Thyroid and androgen receptor signaling are antagonized by μ-Crystallin in prostate cancer.10
296034022018Expression of CRYM in different rat organs during development and its decreased expression in degenerating pyramidal tracts in amyotrophic lateral sclerosis.4
296034022018Expression of CRYM in different rat organs during development and its decreased expression in degenerating pyramidal tracts in amyotrophic lateral sclerosis.4
259311622015Insights into Enzyme Catalysis and Thyroid Hormone Regulation of Cerebral Ketimine Reductase/μ-Crystallin Under Physiological Conditions.10
261735102015Ketimine reductase/CRYM catalyzes reductive alkylamination of α-keto acids, confirming its function as an imine reductase.4
259311622015Insights into Enzyme Catalysis and Thyroid Hormone Regulation of Cerebral Ketimine Reductase/μ-Crystallin Under Physiological Conditions.10
261735102015Ketimine reductase/CRYM catalyzes reductive alkylamination of α-keto acids, confirming its function as an imine reductase.4
235087172013Possible roles of the AP-1 site in the cytosolic T3 binding protein promoter and insights into its physiological significance.1
235087172013Possible roles of the AP-1 site in the cytosolic T3 binding protein promoter and insights into its physiological significance.1
213327202011Mammalian forebrain ketimine reductase identified as μ-crystallin; potential regulation by thyroid hormones.23

Citation

Dessen P

CRYM (crystallin mu)

Atlas Genet Cytogenet Oncol Haematol. 2009-08-01

Online version: http://atlasgeneticsoncology.org/gene/51036/gene-fusions/img/gene-fusions-explorer/