CTSS (cathepsin S)

2009-08-01  

Identity

HGNC
LOCATION
1q21.3
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 1520
MIM: 116845
HGNC: 2545
Ensembl: ENSG00000163131

Variants:

dbSNP: 1520
ClinVar: 1520
TCGA: ENSG00000163131
COSMIC: CTSS

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000163131ENST00000368985P25774
ENSG00000163131ENST00000448301P25774
ENSG00000163131ENST00000472977U3KPS4
ENSG00000163131ENST00000483930U3KQE7

Expression (GTEx)

0
50
100
150
200
250
300

Pathways

PathwaySourceExternal ID
ApoptosisKEGGko04210
Antigen processing and presentationKEGGko04612
ApoptosisKEGGhsa04210
Antigen processing and presentationKEGGhsa04612
LysosomeKEGGko04142
LysosomeKEGGhsa04142
PhagosomeKEGGko04145
PhagosomeKEGGhsa04145
TuberculosisKEGGko05152
TuberculosisKEGGhsa05152
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing-Cross presentationREACTOMER-HSA-1236975
Endosomal/Vacuolar pathwayREACTOMER-HSA-1236977
MHC class II antigen presentationREACTOMER-HSA-2132295
Innate Immune SystemREACTOMER-HSA-168249
Toll-Like Receptors CascadesREACTOMER-HSA-168898
Trafficking and processing of endosomal TLRREACTOMER-HSA-1679131
Extracellular matrix organizationREACTOMER-HSA-1474244
Collagen formationREACTOMER-HSA-1474290
Assembly of collagen fibrils and other multimeric structuresREACTOMER-HSA-2022090
Degradation of the extracellular matrixREACTOMER-HSA-1474228
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
387013652024Elevated Cathepsin S Serum Levels in New-Onset Type 1 Diabetes and Autoantibody-Positive Siblings.0
387013652024Elevated Cathepsin S Serum Levels in New-Onset Type 1 Diabetes and Autoantibody-Positive Siblings.0
369824992023Cathepsin S Knockdown Suppresses Endothelial Inflammation, Angiogenesis, and Complement Protein Activity under Hyperglycemic Conditions In Vitro by Inhibiting NF-κB Signaling.3
370204152023Granulomatous rosacea in Chinese patients: Clinical-histopathological analysis and pathogenesis exploration.0
372633112023Macrophage-Derived Cathepsin S Remodels the Extracellular Matrix to Promote Liver Fibrogenesis.3
369824992023Cathepsin S Knockdown Suppresses Endothelial Inflammation, Angiogenesis, and Complement Protein Activity under Hyperglycemic Conditions In Vitro by Inhibiting NF-κB Signaling.3
370204152023Granulomatous rosacea in Chinese patients: Clinical-histopathological analysis and pathogenesis exploration.0
372633112023Macrophage-Derived Cathepsin S Remodels the Extracellular Matrix to Promote Liver Fibrogenesis.3
350235382022Cathepsin S as an early biomarker for cardiovascular disease in chronic kidney disease patients.3
351864622022Cathepsin S are involved in human carotid atherosclerotic disease progression, mainly by mediating phagosomes: bioinformatics and in vivo and vitro experiments.5
352642092022Knockdown of CD44 inhibits proliferation, migration and invasion of osteosarcoma cells accompanied by downregulation of cathepsin S.7
358680422022Cathepsin S (CTSS) activity in health and disease - A treasure trove of untapped clinical potential.23
350235382022Cathepsin S as an early biomarker for cardiovascular disease in chronic kidney disease patients.3
351864622022Cathepsin S are involved in human carotid atherosclerotic disease progression, mainly by mediating phagosomes: bioinformatics and in vivo and vitro experiments.5
352642092022Knockdown of CD44 inhibits proliferation, migration and invasion of osteosarcoma cells accompanied by downregulation of cathepsin S.7

Citation

Dessen P

CTSS (cathepsin S)

Atlas Genet Cytogenet Oncol Haematol. 2009-08-01

Online version: http://atlasgeneticsoncology.org/gene/51039/gene-fusions/meetings/js/template.js