SLC2A2 (solute carrier family 2 member 2)

2009-09-01 Affiliation

Identity

HGNC

SLC2A2

LOCATION

3q26.2

LOCUSID

6514

ALIAS

GLUT2

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 6514
MIM: 138160
HGNC: 11006
Ensembl: ENSG00000163581

Variants:

dbSNP: 6514
ClinVar: 6514
TCGA: ENSG00000163581
COSMIC: SLC2A2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000163581	ENST00000314251	P11168
ENSG00000163581	ENST00000461867	C9J0E8
ENSG00000163581	ENST00000469787	F8WBJ2
ENSG00000163581	ENST00000497642	A0A0C4DH64

Expression (GTEx)

100

150

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Type II diabetes mellitus	KEGG	ko04930
Maturity onset diabetes of the young	KEGG	ko04950
Type II diabetes mellitus	KEGG	hsa04930
Maturity onset diabetes of the young	KEGG	hsa04950
Carbohydrate digestion and absorption	KEGG	ko04973
Carbohydrate digestion and absorption	KEGG	hsa04973
Insulin secretion	KEGG	hsa04911
Prolactin signaling pathway	KEGG	hsa04917
Prolactin signaling pathway	KEGG	ko04917
Central carbon metabolism in cancer	KEGG	hsa05230
Central carbon metabolism in cancer	KEGG	ko05230
Glucagon signaling pathway	KEGG	hsa04922
Glucagon signaling pathway	KEGG	ko04922
Transmembrane transport of small molecules	REACTOME	R-HSA-382551
SLC-mediated transmembrane transport	REACTOME	R-HSA-425407
Hexose transport	REACTOME	R-HSA-189200
Glucose transport	REACTOME	R-HSA-70153
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds	REACTOME	R-HSA-425366
Facilitative Na+-independent glucose transporters	REACTOME	R-HSA-428790
Metabolism	REACTOME	R-HSA-1430728
Metabolism of carbohydrates	REACTOME	R-HSA-71387
Integration of energy metabolism	REACTOME	R-HSA-163685
Regulation of insulin secretion	REACTOME	R-HSA-422356
Developmental Biology	REACTOME	R-HSA-1266738
Regulation of beta-cell development	REACTOME	R-HSA-186712
Regulation of gene expression in beta cells	REACTOME	R-HSA-210745
Insulin resistance	KEGG	hsa04931

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA443886	Diabetes Mellitus	Disease	ClinicalAnnotation	associated		PD
PA450395	metformin	Chemical	ClinicalAnnotation	associated		PD

References

Pubmed ID	Year	Title	Citations
37257183	2023	Association Between the SLC2A2 Gene rs1499821 Polymorphism and Caries Susceptibility.	0
37884694	2023	The glucose transporter 2 regulates CD8(+) T cell function via environment sensing.	5
37257183	2023	Association Between the SLC2A2 Gene rs1499821 Polymorphism and Caries Susceptibility.	0
37884694	2023	The glucose transporter 2 regulates CD8(+) T cell function via environment sensing.	5
36465606	2022	Decreased expression of Glucagon-like peptide-1 receptor and Sodium-glucose co-transporter 2 in patients with proliferative diabetic retinopathy.	2
36465606	2022	Decreased expression of Glucagon-like peptide-1 receptor and Sodium-glucose co-transporter 2 in patients with proliferative diabetic retinopathy.	2
33199025	2021	Insulinoma induces a hyperinsulinemia-mediated decrease of GLUT2 and GLP1 receptor in normal pancreatic β-cells.	2
34035238	2021	Decreased GLUT2 and glucose uptake contribute to insulin secretion defects in MODY3/HNF1A hiPSC-derived mutant β cells.	27
34215797	2021	Identification of new GLUT2-selective inhibitors through in silico ligand screening and validation in eukaryotic expression systems.	10
34828390	2021	Evidence for a Genotype-Phenotype Correlation in Patients with Pathogenic GLUT2 (SLC2A2) Variants.	2
33199025	2021	Insulinoma induces a hyperinsulinemia-mediated decrease of GLUT2 and GLP1 receptor in normal pancreatic β-cells.	2
34035238	2021	Decreased GLUT2 and glucose uptake contribute to insulin secretion defects in MODY3/HNF1A hiPSC-derived mutant β cells.	27
34215797	2021	Identification of new GLUT2-selective inhibitors through in silico ligand screening and validation in eukaryotic expression systems.	10
34828390	2021	Evidence for a Genotype-Phenotype Correlation in Patients with Pathogenic GLUT2 (SLC2A2) Variants.	2
31407220	2020	Expressions of Carbohydrate Response Element Binding Protein and Glucose Transporters in Liver Cancer and Clinical Significance.	14

Citation

Dessen P

SLC2A2 (solute carrier family 2 member 2)

Atlas Genet Cytogenet Oncol Haematol. 2009-09-01

Online version: http://atlasgeneticsoncology.org/gene/51069