MCRS1 (microspherule protein 1)

2009-09-01 Affiliation

Identity

HGNC

MCRS1

LOCATION

12q13.12

LOCUSID

10445

ALIAS

ICP22BP,INO80Q,MCRS2,MSP58,P78

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 10445
MIM: 609504
HGNC: 6960
Ensembl: ENSG00000187778

Variants:

dbSNP: 10445
ClinVar: 10445
TCGA: ENSG00000187778
COSMIC: MCRS1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000187778	ENST00000343810	Q96EZ8
ENSG00000187778	ENST00000357123	Q96EZ8
ENSG00000187778	ENST00000546244	Q96EZ8
ENSG00000187778	ENST00000546244	A0A024R134
ENSG00000187778	ENST00000548334	F8VP44
ENSG00000187778	ENST00000548596	F8VVA6
ENSG00000187778	ENST00000548602	F8VZC2
ENSG00000187778	ENST00000548646	H0YI67
ENSG00000187778	ENST00000549528	F8W0I9
ENSG00000187778	ENST00000550165	Q96EZ8
ENSG00000187778	ENST00000551598	H0YIA0
ENSG00000187778	ENST00000553173	F8W126

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Herpes simplex infection	KEGG	ko05168
Herpes simplex infection	KEGG	hsa05168
Metabolism of proteins	REACTOME	R-HSA-392499
Post-translational protein modification	REACTOME	R-HSA-597592
DNA Repair	REACTOME	R-HSA-73894
Chromatin organization	REACTOME	R-HSA-4839726
Chromatin modifying enzymes	REACTOME	R-HSA-3247509
HATs acetylate histones	REACTOME	R-HSA-3214847
Nucleotide Excision Repair	REACTOME	R-HSA-5696398
Global Genome Nucleotide Excision Repair (GG-NER)	REACTOME	R-HSA-5696399
DNA Damage Recognition in GG-NER	REACTOME	R-HSA-5696394
Deubiquitination	REACTOME	R-HSA-5688426
UCH proteinases	REACTOME	R-HSA-5689603

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
36350698	2023	MCRS1 modulates the heterogeneity of microtubule minus-end morphologies in mitotic spindles.	1
36384428	2023	The molecular characteristics and functional roles of microspherule protein 1 (MCRS1) in gene expression, cell proliferation, and organismic development.	0
36350698	2023	MCRS1 modulates the heterogeneity of microtubule minus-end morphologies in mitotic spindles.	1
36384428	2023	The molecular characteristics and functional roles of microspherule protein 1 (MCRS1) in gene expression, cell proliferation, and organismic development.	0
30785839	2019	Mps1 regulates spindle morphology through MCRS1 to promote chromosome alignment.	6
30953699	2019	Effects of MCRS1 on proliferation, migration, invasion, and epithelial mesenchymal transition of gastric cancer cells by interacting with Pkmyt1 protein kinase.	12
31140612	2019	miR-186 modulates hepatocellular carcinoma cell proliferation and mobility via targeting MCRS1-mediated Wnt/β-catenin signaling.	12
30785839	2019	Mps1 regulates spindle morphology through MCRS1 to promote chromosome alignment.	6
30953699	2019	Effects of MCRS1 on proliferation, migration, invasion, and epithelial mesenchymal transition of gastric cancer cells by interacting with Pkmyt1 protein kinase.	12
31140612	2019	miR-186 modulates hepatocellular carcinoma cell proliferation and mobility via targeting MCRS1-mediated Wnt/β-catenin signaling.	12
28448870	2017	Knockdown of MSP58 inhibits the proliferation and metastasis in human renal cell carcinoma cells.	2
28448870	2017	Knockdown of MSP58 inhibits the proliferation and metastasis in human renal cell carcinoma cells.	2
26849376	2016	Expression of 58-kD Microspherule Protein (MSP58) is Highly Correlated with PET Imaging of Tumor Malignancy and Cell Proliferation in Glioma Patients.	3
27192185	2016	Aurora-A regulates MCRS1 function during mitosis.	4
27263857	2016	MCRS1 associates with cytoplasmic dynein and mediates pericentrosomal material recruitment.	9

Citation

Dessen P

MCRS1 (microspherule protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2009-09-01

Online version: http://atlasgeneticsoncology.org/gene/51076/gene-fusions/js/lib/css/cancer-prone-explorer/