SLC2A8 (solute carrier family 2 member 8)

2009-09-01  

Identity

HGNC
SLC2A8
LOCATION
9q33.3
LOCUSID
29988
ALIAS
GLUT8,GLUTX1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 29988
MIM: 605245
HGNC: 13812
Ensembl: ENSG00000136856

Variants:

dbSNP: 29988
ClinVar: 29988
TCGA: ENSG00000136856
COSMIC: SLC2A8

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000136856ENST00000373352Q5VVW5
ENSG00000136856ENST00000373360Q5VVV9
ENSG00000136856ENST00000373371Q9NY64
ENSG00000136856ENST00000373371A0A024R871
ENSG00000136856ENST00000419132H0Y7M6
ENSG00000136856ENST00000419917Q5VVW0
ENSG00000136856ENST00000423934Q5VVV5
ENSG00000136856ENST00000430147Q5VVV4
ENSG00000136856ENST00000439597Q5VVV6
ENSG00000136856ENST00000451404Q5VVV3
ENSG00000136856ENST00000610552A0A087WT42

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compoundsREACTOMER-HSA-425366
Facilitative Na+-independent glucose transportersREACTOMER-HSA-428790
Clathrin-mediated endocytosisREACTOMER-HSA-8856828
Cargo recognition for clathrin-mediated endocytosisREACTOMER-HSA-8856825

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
295901292018Humanin (HN) and glucose transporter 8 (GLUT8) in pregnancies complicated by intrauterine growth restriction.11
295901292018Humanin (HN) and glucose transporter 8 (GLUT8) in pregnancies complicated by intrauterine growth restriction.11
278183552017Glucose transporter 8 immunoreactivity in astrocytic and microglial cells in subependymal areas of human brains.4
278183552017Glucose transporter 8 immunoreactivity in astrocytic and microglial cells in subependymal areas of human brains.4
271600962016Immunoreactivity of glucose transporter 8 is localized in the epithelial cells of the choroid plexus and in ependymal cells.7
279221022016SLC2A8 (GLUT8) is a mammalian trehalose transporter required for trehalose-induced autophagy.54
271600962016Immunoreactivity of glucose transporter 8 is localized in the epithelial cells of the choroid plexus and in ependymal cells.7
279221022016SLC2A8 (GLUT8) is a mammalian trehalose transporter required for trehalose-induced autophagy.54
245199322014Glucose transporter 8 (GLUT8) mediates fructose-induced de novo lipogenesis and macrosteatosis.54
245199322014Glucose transporter 8 (GLUT8) mediates fructose-induced de novo lipogenesis and macrosteatosis.54
232348772013Gene expression profiling of peripheral blood leukocytes shows consistent longitudinal downregulation of TOMM40 and upregulation of KIR2DL5A, PLOD1, and SLC2A8 among fast progressors in early Alzheimer's disease.20
232348772013Gene expression profiling of peripheral blood leukocytes shows consistent longitudinal downregulation of TOMM40 and upregulation of KIR2DL5A, PLOD1, and SLC2A8 among fast progressors in early Alzheimer's disease.20
224529792012Multiple myeloma exhibits novel dependence on GLUT4, GLUT8, and GLUT11: implications for glucose transporter-directed therapy.99
224529792012Multiple myeloma exhibits novel dependence on GLUT4, GLUT8, and GLUT11: implications for glucose transporter-directed therapy.99
209657182011Genetic variability of the fatty acid synthase pathway is not associated with prostate cancer risk in the European Prospective Investigation on Cancer (EPIC).4

Citation

Dessen P

SLC2A8 (solute carrier family 2 member 8)

Atlas Genet Cytogenet Oncol Haematol. 2009-09-01

Online version: http://atlasgeneticsoncology.org/gene/51120/js/lib/gene-fusions-explorer/