SIK3 (SIK family kinase 3)

2009-09-01  

Identity

HGNC
SIK3
LOCATION
11q23.3
LOCUSID
23387
ALIAS
L19,QSK,SEMDK,SIK-3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 23387
MIM: 614776
HGNC: 29165
Ensembl: ENSG00000160584

Variants:

dbSNP: 23387
ClinVar: 23387
TCGA: ENSG00000160584
COSMIC: SIK3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000160584ENST00000375300Q9Y2K2
ENSG00000160584ENST00000413553H7C3X8
ENSG00000160584ENST00000415541H7C038
ENSG00000160584ENST00000445177H0Y4E8
ENSG00000160584ENST00000446921Q9Y2K2
ENSG00000160584ENST00000454905H7C042

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
380573702024Targeting SIK3 to modulate hippocampal synaptic plasticity and cognitive function by regulating the transcription of HDAC4 in a mouse model of Alzheimer's disease.0
380573702024Targeting SIK3 to modulate hippocampal synaptic plasticity and cognitive function by regulating the transcription of HDAC4 in a mouse model of Alzheimer's disease.0
348395132021[Analysis of SIK3 gene variation in a boy with autism spectrum disorder complicated with epilepsy].0
348395132021[Analysis of SIK3 gene variation in a boy with autism spectrum disorder complicated with epilepsy].0
318492502020High-Throughput Implementation of the NanoBRET Target Engagement Intracellular Kinase Assay to Reveal Differential Compound Engagement by SIK2/3 Isoforms.5
319695562020Salt-inducible kinases (SIKs) regulate TGFβ-mediated transcriptional and apoptotic responses.7
321265662020Salt-Inducible Kinase 3 Haplotypes Associated with Noise-Induced Hearing Loss in Chinese Workers.2
323437712020Salt-inducible Kinases Are Critical Determinants of Female Fertility.7
318492502020High-Throughput Implementation of the NanoBRET Target Engagement Intracellular Kinase Assay to Reveal Differential Compound Engagement by SIK2/3 Isoforms.5
319695562020Salt-inducible kinases (SIKs) regulate TGFβ-mediated transcriptional and apoptotic responses.7
321265662020Salt-Inducible Kinase 3 Haplotypes Associated with Noise-Induced Hearing Loss in Chinese Workers.2
323437712020Salt-inducible Kinases Are Critical Determinants of Female Fertility.7
313503272019An LKB1-SIK Axis Suppresses Lung Tumor Growth and Controls Differentiation.43
313503272019An LKB1-SIK Axis Suppresses Lung Tumor Growth and Controls Differentiation.43
29211348201814-3-3 proteins mediate inhibitory effects of cAMP on salt-inducible kinases (SIKs).33

Citation

Dessen P

SIK3 (SIK family kinase 3)

Atlas Genet Cytogenet Oncol Haematol. 2009-09-01

Online version: http://atlasgeneticsoncology.org/gene/51135