DHRS2 (dehydrogenase/reductase 2)

2009-09-01  

Identity

HGNC
DHRS2
LOCATION
14q11.2
LOCUSID
10202
ALIAS
HEP27,SDR25C1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10202
MIM: 615194
HGNC: 18349
Ensembl: ENSG00000100867

Variants:

dbSNP: 10202
ClinVar: 10202
TCGA: ENSG00000100867
COSMIC: DHRS2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000100867ENST00000250383Q13268
ENSG00000100867ENST00000344777Q13268
ENSG00000100867ENST00000432832C9JZP6
ENSG00000100867ENST00000553600H0YJG9
ENSG00000100867ENST00000557535H0YJP4
ENSG00000100867ENST00000611765Q13268

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
370607452023Regulatory mechanism of DHRS2-modified human umbilical cord mesenchymal stem cells-derived exosomes in prostate cancer cell proliferation and apoptosis.1
371197642023Epigenetic regulation of DHRS2 by SUV420H2 inhibits cell apoptosis in renal cell carcinoma.1
370607452023Regulatory mechanism of DHRS2-modified human umbilical cord mesenchymal stem cells-derived exosomes in prostate cancer cell proliferation and apoptosis.1
371197642023Epigenetic regulation of DHRS2 by SUV420H2 inhibits cell apoptosis in renal cell carcinoma.1
361923912022DHRS2 inhibits cell growth and metastasis in ovarian cancer by downregulation of CHKα to disrupt choline metabolism.4
361923912022DHRS2 inhibits cell growth and metastasis in ovarian cancer by downregulation of CHKα to disrupt choline metabolism.4
314238952020Decreased DHRS2 expression is associated with HDACi resistance and poor prognosis in ovarian cancer.8
325860852020LEF1 Induces DHRS2 Gene Expression in Human Acute Leukemia Jurkat T-Cells.1
314238952020Decreased DHRS2 expression is associated with HDACi resistance and poor prognosis in ovarian cancer.8
325860852020LEF1 Induces DHRS2 Gene Expression in Human Acute Leukemia Jurkat T-Cells.1
304607722019Deciphering the molecular effects of romidepsin on germ cell tumours: DHRS2 is involved in cell cycle arrest but not apoptosis or induction of romidepsin effectors.15
305354632019Molecular pathogenesis of esophageal squamous cell carcinoma: Identification of the antitumor effects of miR‑145‑3p on gene regulation.18
312919712019DHRS2 mediates cell growth inhibition induced by Trichothecin in nasopharyngeal carcinoma.16
314363012019Dehydrogenase/reductase SDR family member 2 silencing sensitizes an oxaliplatin‑resistant cell line to oxaliplatin by inhibiting excision repair cross‑complementing group 1 protein expression.3
304607722019Deciphering the molecular effects of romidepsin on germ cell tumours: DHRS2 is involved in cell cycle arrest but not apoptosis or induction of romidepsin effectors.15

Citation

Dessen P

DHRS2 (dehydrogenase/reductase 2)

Atlas Genet Cytogenet Oncol Haematol. 2009-09-01

Online version: http://atlasgeneticsoncology.org/gene/51136