Identity
HGNC
LOCATION
14q12
LOCUSID
ALIAS
HR21spB,REC8L1,Rec8p
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 9985
MIM: 608193
HGNC: 16879
Ensembl: ENSG00000100918
Variants:
dbSNP: 9985
ClinVar: 9985
TCGA: ENSG00000100918
COSMIC: REC8
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Oocyte meiosis | KEGG | ko04114 |
| Oocyte meiosis | KEGG | hsa04114 |
| Cell Cycle | REACTOME | R-HSA-1640170 |
| Meiosis | REACTOME | R-HSA-1500620 |
| Meiotic synapsis | REACTOME | R-HSA-1221632 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38105365 | 2023 | REC8 regulates neuroblastoma cell proliferation, migration, invasion, and angiogenesis via STAT3/VEGF signaling. | 0 |
| 38105365 | 2023 | REC8 regulates neuroblastoma cell proliferation, migration, invasion, and angiogenesis via STAT3/VEGF signaling. | 0 |
| 34707299 | 2022 | Meiotic genes in premature ovarian insufficiency: variants in HROB and REC8 as likely genetic causes. | 12 |
| 35616161 | 2022 | REC8 inhibits proliferation, migration and invasion of breast cancer cells by targeting CDC20. | 3 |
| 34707299 | 2022 | Meiotic genes in premature ovarian insufficiency: variants in HROB and REC8 as likely genetic causes. | 12 |
| 35616161 | 2022 | REC8 inhibits proliferation, migration and invasion of breast cancer cells by targeting CDC20. | 3 |
| 33658710 | 2021 | Centromeres are dismantled by foundational meiotic proteins Spo11 and Rec8. | 12 |
| 33677646 | 2021 | REC8 promotes tumor migration, invasion and angiogenesis by targeting the PKA pathway in hepatocellular carcinoma. | 6 |
| 33658710 | 2021 | Centromeres are dismantled by foundational meiotic proteins Spo11 and Rec8. | 12 |
| 33677646 | 2021 | REC8 promotes tumor migration, invasion and angiogenesis by targeting the PKA pathway in hepatocellular carcinoma. | 6 |
| 32958054 | 2020 | REC8 suppresses tumor angiogenesis by inhibition of NF-κB-mediated vascular endothelial growth factor expression in gastric cancer cells. | 10 |
| 32958054 | 2020 | REC8 suppresses tumor angiogenesis by inhibition of NF-κB-mediated vascular endothelial growth factor expression in gastric cancer cells. | 10 |
| 29393474 | 2018 | REC8 inhibits EMT by downregulating EGR1 in gastric cancer cells. | 23 |
| 29724914 | 2018 | Studying meiotic cohesin in somatic cells reveals that Rec8-containing cohesin requires Stag3 to function and is regulated by Wapl and sororin. | 13 |
| 29393474 | 2018 | REC8 inhibits EMT by downregulating EGR1 in gastric cancer cells. | 23 |
Citation
Dessen P
REC8 (REC8 meiotic recombination protein)
Atlas Genet Cytogenet Oncol Haematol. 2009-10-01
Online version: http://atlasgeneticsoncology.org/gene/51164/rec8
