KCNJ4 (potassium inwardly rectifying channel subfamily J member 4)

2009-11-01 Affiliation

Identity

HGNC

KCNJ4

LOCATION

22q13.1

LOCUSID

3761

ALIAS

HIR,HIRK2,HRK1,IRK-3,IRK3,Kir2.3

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 3761
MIM: 600504
HGNC: 6265
Ensembl: ENSG00000168135

Variants:

dbSNP: 3761
ClinVar: 3761
TCGA: ENSG00000168135
COSMIC: KCNJ4

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000168135	ENST00000303592	P48050
ENSG00000168135	ENST00000303592	A0A024R1L8

Expression (GTEx)

100

150

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Cholinergic synapse	KEGG	hsa04725
Oxytocin signaling pathway	KEGG	hsa04921
Oxytocin signaling pathway	KEGG	ko04921
Neuronal System	REACTOME	R-HSA-112316
Transmission across Chemical Synapses	REACTOME	R-HSA-112315
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell	REACTOME	R-HSA-112314
GABA receptor activation	REACTOME	R-HSA-977443
GABA B receptor activation	REACTOME	R-HSA-977444
Activation of GABAB receptors	REACTOME	R-HSA-991365
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	REACTOME	R-HSA-997272
Potassium Channels	REACTOME	R-HSA-1296071
Inwardly rectifying K+ channels	REACTOME	R-HSA-1296065
G protein gated Potassium channels	REACTOME	R-HSA-1296059
Activation of G protein gated Potassium channels	REACTOME	R-HSA-1296041
Classical Kir channels	REACTOME	R-HSA-1296053
Muscle contraction	REACTOME	R-HSA-397014
Cardiac conduction	REACTOME	R-HSA-5576891
Phase 4 - resting membrane potential	REACTOME	R-HSA-5576886

References

Pubmed ID	Year	Title	Citations
30512237	2019	Overexpression of KCNJ4 correlates with cancer progression and unfavorable prognosis in lung adenocarcinoma.	7
30512237	2019	Overexpression of KCNJ4 correlates with cancer progression and unfavorable prognosis in lung adenocarcinoma.	7
22396414	2012	Striatal D2 receptors regulate dendritic morphology of medium spiny neurons via Kir2 channels.	64
22396414	2012	Striatal D2 receptors regulate dendritic morphology of medium spiny neurons via Kir2 channels.	64
20424473	2010	L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms.	0
20424473	2010	L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms.	0
19635485	2009	Molecular mechanism of inward rectifier potassium channel 2.3 regulation by tax-interacting protein-1.	13
19635485	2009	Molecular mechanism of inward rectifier potassium channel 2.3 regulation by tax-interacting protein-1.	13
18180291	2008	AP-2-dependent internalization of potassium channel Kir2.3 is driven by a novel di-hydrophobic signal.	21
18453743	2008	Novel insights into the structural basis of pH-sensitivity in inward rectifier K+ channels Kir2.3.	4
18503768	2008	Kir2.3 knock-down decreases IK1 current in neonatal rat cardiomyocytes.	4
18180291	2008	AP-2-dependent internalization of potassium channel Kir2.3 is driven by a novel di-hydrophobic signal.	21
18453743	2008	Novel insights into the structural basis of pH-sensitivity in inward rectifier K+ channels Kir2.3.	4
18503768	2008	Kir2.3 knock-down decreases IK1 current in neonatal rat cardiomyocytes.	4
16258766	2006	Regulation of cardiac inwardly rectifying potassium current IK1 and Kir2.x channels by endothelin-1.	8

Citation

Dessen P

KCNJ4 (potassium inwardly rectifying channel subfamily J member 4)

Atlas Genet Cytogenet Oncol Haematol. 2009-11-01

Online version: http://atlasgeneticsoncology.org/gene/51194