MAP1LC3B (microtubule associated protein 1 light chain 3 beta)

2009-11-01  

Identity

HGNC
MAP1LC3B
LOCATION
16q24.2
LOCUSID
81631
ALIAS
ATG8F,LC3B,MAP1A/1BLC3,MAP1LC3B-a
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 81631
MIM: 609604
HGNC: 13352
Ensembl: ENSG00000140941

Variants:

dbSNP: 81631
ClinVar: 81631
TCGA: ENSG00000140941
COSMIC: MAP1LC3B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000140941ENST00000268607Q9GZQ8
ENSG00000140941ENST00000268607Q658J6
ENSG00000140941ENST00000564844H3BM99
ENSG00000140941ENST00000565788H3BTL1
ENSG00000140941ENST00000570189H3BTE7
ENSG00000140941ENST00000650688Q9GZQ8
ENSG00000140941ENST00000650688Q658J6

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Cellular responses to stressREACTOMER-HSA-2262752
MacroautophagyREACTOMER-HSA-1632852
MitophagyREACTOMER-HSA-5205647
Pink/Parkin Mediated MitophagyREACTOMER-HSA-5205685
TBC/RABGAPsREACTOMER-HSA-8854214
FerroptosisKEGGko04216
FerroptosisKEGGhsa04216

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
382857782024Immunohistochemical Expression of Autophagy-Related Marker (LC3B) and Stem Cell Marker (CD44) in Molecular Subtypes of Breast Cancer.0
383886612024Identifying CTH and MAP1LC3B as ferroptosis biomarkers for prognostic indication in gastric cancer decoding.0
384122402024LC3B drives transcription-associated homologous recombination via direct interaction with R-loops.1
385278042024Linc00673-V3 positively regulates autophagy by promoting Smad3-mediated LC3B transcription in NSCLC.0
382857782024Immunohistochemical Expression of Autophagy-Related Marker (LC3B) and Stem Cell Marker (CD44) in Molecular Subtypes of Breast Cancer.0
383886612024Identifying CTH and MAP1LC3B as ferroptosis biomarkers for prognostic indication in gastric cancer decoding.0
384122402024LC3B drives transcription-associated homologous recombination via direct interaction with R-loops.1
385278042024Linc00673-V3 positively regulates autophagy by promoting Smad3-mediated LC3B transcription in NSCLC.0
355749462023SQSTM1 and its MAP1LC3B-binding domain induce forced mitophagy to degrade mitochondrial carryover during mitochondrial replacement therapy.0
367196342023Alterations of ATG4A and LC3B in neurons derived from Alzheimer's disease patients.0
373155622023LC3B is lipidated to large lipid droplets during prolonged starvation for noncanonical autophagy.5
355749462023SQSTM1 and its MAP1LC3B-binding domain induce forced mitophagy to degrade mitochondrial carryover during mitochondrial replacement therapy.0
367196342023Alterations of ATG4A and LC3B in neurons derived from Alzheimer's disease patients.0
373155622023LC3B is lipidated to large lipid droplets during prolonged starvation for noncanonical autophagy.5
356335642022The Pathological Evaluation of Autophagy-Related Protein (LC3B) and Its Association with the Infiltration of Immune Cells in Glioma.1

Citation

Dessen P

MAP1LC3B (microtubule associated protein 1 light chain 3 beta)

Atlas Genet Cytogenet Oncol Haematol. 2009-11-01

Online version: http://atlasgeneticsoncology.org/gene/51202