NPEPPS (aminopeptidase puromycin sensitive)

2009-11-01  

Identity

HGNC
NPEPPS
LOCATION
17q21.32
LOCUSID
9520
ALIAS
AAP-S,MP100,PSA
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9520
MIM: 606793
HGNC: 7900
Ensembl: ENSG00000141279

Variants:

dbSNP: 9520
ClinVar: 9520
TCGA: ENSG00000141279
COSMIC: NPEPPS

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000141279ENST00000322157P55786
ENSG00000141279ENST00000525007E9PP11
ENSG00000141279ENST00000525048H0YCQ5
ENSG00000141279ENST00000526247E9PJF9
ENSG00000141279ENST00000527298E9PPD4
ENSG00000141279ENST00000527360E9PRQ5
ENSG00000141279ENST00000527964E9PJ74
ENSG00000141279ENST00000528565H0YDG0
ENSG00000141279ENST00000530173E9PLK3
ENSG00000141279ENST00000530514E9PI82
ENSG00000141279ENST00000532729E9PPZ2
ENSG00000141279ENST00000534691E9PJY4

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
340485662021PSA controls hepatic lipid metabolism by regulating the NRF2 signaling pathway.4
340485662021PSA controls hepatic lipid metabolism by regulating the NRF2 signaling pathway.4
315230442020Analysis of 47 Non-MHC Ankylosing Spondylitis Susceptibility Loci Regarding Associated Variants across Whites and Han Chinese.2
315230442020Analysis of 47 Non-MHC Ankylosing Spondylitis Susceptibility Loci Regarding Associated Variants across Whites and Han Chinese.2
260787062015Altered Activity and Expression of Cytosolic Peptidases in Colorectal Cancer.4
260787062015Altered Activity and Expression of Cytosolic Peptidases in Colorectal Cancer.4
251420312014Genetic associations and functional characterization of M1 aminopeptidases and immune-mediated diseases.20
253420372014[MiR-614 inhibited lung cancer cell invasion and proliferation via targeting PSA].1
251420312014Genetic associations and functional characterization of M1 aminopeptidases and immune-mediated diseases.20
253420372014[MiR-614 inhibited lung cancer cell invasion and proliferation via targeting PSA].1
213208712011Puromycin-sensitive aminopeptidase (PSA/NPEPPS) impedes development of neuropathology in hPSA/TAU(P301L) double-transgenic mice.20
213208712011Puromycin-sensitive aminopeptidase (PSA/NPEPPS) impedes development of neuropathology in hPSA/TAU(P301L) double-transgenic mice.20
208292252010Puromycin-sensitive aminopeptidase protects against aggregation-prone proteins via autophagy.33
208292252010Puromycin-sensitive aminopeptidase protects against aggregation-prone proteins via autophagy.33
194947032009Cobalt chloride-induced downregulation of puromycin-sensitive aminopeptidase suppresses the migration and invasion of PC-3 cells.1

Citation

Dessen P

NPEPPS (aminopeptidase puromycin sensitive)

Atlas Genet Cytogenet Oncol Haematol. 2009-11-01

Online version: http://atlasgeneticsoncology.org/gene/51212