MSL1 (MSL complex subunit 1)

2009-11-01  

Identity

HGNC
MSL1
LOCATION
17q21.1
LOCUSID
339287
ALIAS
MSL-1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 339287
MIM: 614801
HGNC: 27905
Ensembl: ENSG00000188895

Variants:

dbSNP: 339287
ClinVar: 339287
TCGA: ENSG00000188895
COSMIC: MSL1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000188895ENST00000398532Q68DK7
ENSG00000188895ENST00000577454J3QQY0
ENSG00000188895ENST00000578648J3KSZ8
ENSG00000188895ENST00000579565Q68DK7
ENSG00000188895ENST00000582884J3KTC2
ENSG00000188895ENST00000582920J3KRQ4

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Chromatin organizationREACTOMER-HSA-4839726
Chromatin modifying enzymesREACTOMER-HSA-3247509
HATs acetylate histonesREACTOMER-HSA-3214847

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
346445772021Shift in MSL1 alternative polyadenylation in response to DNA damage protects cancer cells from chemotherapeutic agent-induced apoptosis.9
346445772021Shift in MSL1 alternative polyadenylation in response to DNA damage protects cancer cells from chemotherapeutic agent-induced apoptosis.9
249139092014Two distinct nuclear localization signals in mammalian MSL1 regulate its function.0
249139092014Two distinct nuclear localization signals in mammalian MSL1 regulate its function.0
242051102013Deciphering the binding between Nupr1 and MSL1 and their DNA-repairing activity.22
242051102013Deciphering the binding between Nupr1 and MSL1 and their DNA-repairing activity.22
196500742009p8/nupr1 regulates DNA-repair activity after double-strand gamma irradiation-induced DNA damage.28
196500742009p8/nupr1 regulates DNA-repair activity after double-strand gamma irradiation-induced DNA damage.28
162275712005A human protein complex homologous to the Drosophila MSL complex is responsible for the majority of histone H4 acetylation at lysine 16.170
162275712005A human protein complex homologous to the Drosophila MSL complex is responsible for the majority of histone H4 acetylation at lysine 16.170

Citation

Dessen P

MSL1 (MSL complex subunit 1)

Atlas Genet Cytogenet Oncol Haematol. 2009-11-01

Online version: http://atlasgeneticsoncology.org/gene/51219/teaching-explorer/case-report-explorer/js/lib/all.min.js