UGT8 (UDP glycosyltransferase 8)

2010-01-01  

Identity

HGNC
LOCATION
4q26
LOCUSID
ALIAS
CGT,UGT4
FUSION GENES

Other Information

Locus ID:

NCBI: 7368
MIM: 601291
HGNC: 12555
Ensembl: ENSG00000174607

Variants:

dbSNP: 7368
ClinVar: 7368
TCGA: ENSG00000174607
COSMIC: UGT8

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000174607ENST00000310836Q16880
ENSG00000174607ENST00000394511Q16880
ENSG00000174607ENST00000507710D6RFW2

Expression (GTEx)

0
50
100
150
200
250
300

Pathways

PathwaySourceExternal ID
Ether lipid metabolismKEGGko00565
Sphingolipid metabolismKEGGko00600
Ether lipid metabolismKEGGhsa00565
Sphingolipid metabolismKEGGhsa00600
Metabolic pathwaysKEGGhsa01100
Sulfoglycolipids biosynthesis, ceramide/1-alkyl-2-acylglycerol => sulfatide/seminolipidKEGGhsa_M00067
Sulfoglycolipids biosynthesis, ceramide/1-alkyl-2-acylglycerol => sulfatide/seminolipidKEGGM00067
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Sphingolipid metabolismREACTOMER-HSA-428157
Glycosphingolipid metabolismREACTOMER-HSA-1660662

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
348720022022SOX9-mediated UGT8 expression promotes glycolysis and maintains the malignancy of non-small cell lung cancer.5
348720022022SOX9-mediated UGT8 expression promotes glycolysis and maintains the malignancy of non-small cell lung cancer.5
314097412019High FA2H and UGT8 transcript levels predict hydroxylated hexosylceramide accumulation in lung adenocarcinoma.11
314097412019High FA2H and UGT8 transcript levels predict hydroxylated hexosylceramide accumulation in lung adenocarcinoma.11
297284412018Inhibition of UGT8 suppresses basal-like breast cancer progression by attenuating sulfatide-αVβ5 axis.31
297284412018Inhibition of UGT8 suppresses basal-like breast cancer progression by attenuating sulfatide-αVβ5 axis.31
287463572017Microbubble-based enhancement of radiation effect: Role of cell membrane ceramide metabolism.21
287463572017Microbubble-based enhancement of radiation effect: Role of cell membrane ceramide metabolism.21
276203102016Expression of Ceramide Galactosyltransferase (UGT8) in Primary and Metastatic Lung Tissues of Non-Small-Cell Lung Cancer.3
276203102016Expression of Ceramide Galactosyltransferase (UGT8) in Primary and Metastatic Lung Tissues of Non-Small-Cell Lung Cancer.3
255198372015A novel function for UDP glycosyltransferase 8: galactosidation of bile acids.14
255198372015A novel function for UDP glycosyltransferase 8: galactosidation of bile acids.14
248214922014Ceramide galactosyltransferase expression is regulated positively by Nkx2.2 and negatively by OLIG2.3
248214922014Ceramide galactosyltransferase expression is regulated positively by Nkx2.2 and negatively by OLIG2.3
243919082013Galactosylceramide affects tumorigenic and metastatic properties of breast cancer cells as an anti-apoptotic molecule.21

Citation

Dessen P

UGT8 (UDP glycosyltransferase 8)

Atlas Genet Cytogenet Oncol Haematol. 2010-01-01

Online version: http://atlasgeneticsoncology.org/gene/51263/ugt8