Identity
HGNC
LOCATION
5q31.2
LOCUSID
ALIAS
SMAP,SMAP2,p120
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 10902
MIM: 602848
HGNC: 19874
Ensembl: ENSG00000112983
Variants:
dbSNP: 10902
ClinVar: 10902
TCGA: ENSG00000112983
COSMIC: BRD8
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Chromatin organization | REACTOME | R-HSA-4839726 |
| Chromatin modifying enzymes | REACTOME | R-HSA-3247509 |
| HATs acetylate histones | REACTOME | R-HSA-3214847 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36544023 | 2023 | BRD8 maintains glioblastoma by epigenetic reprogramming of the p53 network. | 10 |
| 36544023 | 2023 | BRD8 maintains glioblastoma by epigenetic reprogramming of the p53 network. | 10 |
| 33476703 | 2021 | The Bromodomain Containing 8 (BRD8) transcriptional network in human lung epithelial cells. | 6 |
| 33476703 | 2021 | The Bromodomain Containing 8 (BRD8) transcriptional network in human lung epithelial cells. | 6 |
| 32860757 | 2020 | BRD8, which is negatively regulated by miR-876-3p, promotes the proliferation and apoptosis resistance of hepatocellular carcinoma cells via KAT5. | 6 |
| 32860757 | 2020 | BRD8, which is negatively regulated by miR-876-3p, promotes the proliferation and apoptosis resistance of hepatocellular carcinoma cells via KAT5. | 6 |
| 30237520 | 2018 | Cellular Depletion of BRD8 Causes p53-Dependent Apoptosis and Induces a DNA Damage Response in Non-Stressed Cells. | 10 |
| 30237520 | 2018 | Cellular Depletion of BRD8 Causes p53-Dependent Apoptosis and Induces a DNA Damage Response in Non-Stressed Cells. | 10 |
| 26940039 | 2016 | MiR-185 attenuates androgen receptor function in prostate cancer indirectly by targeting bromodomain containing 8 isoform 2, an androgen receptor co-activator. | 14 |
| 26940039 | 2016 | MiR-185 attenuates androgen receptor function in prostate cancer indirectly by targeting bromodomain containing 8 isoform 2, an androgen receptor co-activator. | 14 |
| 23064015 | 2012 | The p400/Brd8 chromatin remodeling complex promotes adipogenesis by incorporating histone variant H2A.Z at PPARγ target genes. | 11 |
| 23064015 | 2012 | The p400/Brd8 chromatin remodeling complex promotes adipogenesis by incorporating histone variant H2A.Z at PPARγ target genes. | 11 |
| 19787264 | 2009 | BRD8 is a potential chemosensitizing target for spindle poisons in colorectal cancer therapy. | 14 |
| 19787264 | 2009 | BRD8 is a potential chemosensitizing target for spindle poisons in colorectal cancer therapy. | 14 |
| 16571680 | 2006 | SMAP2, a novel ARF GTPase-activating protein, interacts with clathrin and clathrin assembly protein and functions on the AP-1-positive early endosome/trans-Golgi network. | 28 |
Citation
Dessen P
BRD8 (bromodomain containing 8)
Atlas Genet Cytogenet Oncol Haematol. 2010-01-01
Online version: http://atlasgeneticsoncology.org/gene/51290/brd8
