BRD8 (bromodomain containing 8)

2010-01-01  

Identity

HGNC
BRD8
LOCATION
5q31.2
LOCUSID
10902
ALIAS
SMAP,SMAP2,p120
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10902
MIM: 602848
HGNC: 19874
Ensembl: ENSG00000112983

Variants:

dbSNP: 10902
ClinVar: 10902
TCGA: ENSG00000112983
COSMIC: BRD8

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000112983ENST00000230901Q9H0E9
ENSG00000112983ENST00000254900Q9H0E9
ENSG00000112983ENST00000402931B5MCW3
ENSG00000112983ENST00000411594Q9H0E9
ENSG00000112983ENST00000418329H7C179
ENSG00000112983ENST00000427976H7C026
ENSG00000112983ENST00000428808F8WDX5
ENSG00000112983ENST00000430331C9JV05
ENSG00000112983ENST00000432618F8WBH2
ENSG00000112983ENST00000441656H7C128
ENSG00000112983ENST00000450756F8WCS7
ENSG00000112983ENST00000453824H7C2P4
ENSG00000112983ENST00000454473H7C127
ENSG00000112983ENST00000472478H0Y8F9
ENSG00000112983ENST00000506167H0YAH7
ENSG00000112983ENST00000511898H0YA84
ENSG00000112983ENST00000512140D6RID0

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Chromatin organizationREACTOMER-HSA-4839726
Chromatin modifying enzymesREACTOMER-HSA-3247509
HATs acetylate histonesREACTOMER-HSA-3214847

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
365440232023BRD8 maintains glioblastoma by epigenetic reprogramming of the p53 network.10
365440232023BRD8 maintains glioblastoma by epigenetic reprogramming of the p53 network.10
334767032021The Bromodomain Containing 8 (BRD8) transcriptional network in human lung epithelial cells.6
334767032021The Bromodomain Containing 8 (BRD8) transcriptional network in human lung epithelial cells.6
328607572020BRD8, which is negatively regulated by miR-876-3p, promotes the proliferation and apoptosis resistance of hepatocellular carcinoma cells via KAT5.6
328607572020BRD8, which is negatively regulated by miR-876-3p, promotes the proliferation and apoptosis resistance of hepatocellular carcinoma cells via KAT5.6
302375202018Cellular Depletion of BRD8 Causes p53-Dependent Apoptosis and Induces a DNA Damage Response in Non-Stressed Cells.10
302375202018Cellular Depletion of BRD8 Causes p53-Dependent Apoptosis and Induces a DNA Damage Response in Non-Stressed Cells.10
269400392016MiR-185 attenuates androgen receptor function in prostate cancer indirectly by targeting bromodomain containing 8 isoform 2, an androgen receptor co-activator.14
269400392016MiR-185 attenuates androgen receptor function in prostate cancer indirectly by targeting bromodomain containing 8 isoform 2, an androgen receptor co-activator.14
230640152012The p400/Brd8 chromatin remodeling complex promotes adipogenesis by incorporating histone variant H2A.Z at PPARγ target genes.11
230640152012The p400/Brd8 chromatin remodeling complex promotes adipogenesis by incorporating histone variant H2A.Z at PPARγ target genes.11
197872642009BRD8 is a potential chemosensitizing target for spindle poisons in colorectal cancer therapy.14
197872642009BRD8 is a potential chemosensitizing target for spindle poisons in colorectal cancer therapy.14
165716802006SMAP2, a novel ARF GTPase-activating protein, interacts with clathrin and clathrin assembly protein and functions on the AP-1-positive early endosome/trans-Golgi network.28

Citation

Dessen P

BRD8 (bromodomain containing 8)

Atlas Genet Cytogenet Oncol Haematol. 2010-01-01

Online version: http://atlasgeneticsoncology.org/gene/51290/gene-fusions/gene-fusions/favicon/apple-touch-icon.png