BRD8 (bromodomain containing 8)

2010-01-01  

Identity

HGNC
LOCATION
5q31.2
LOCUSID
ALIAS
SMAP,SMAP2,p120
FUSION GENES

Other Information

Locus ID:

NCBI: 10902
MIM: 602848
HGNC: 19874
Ensembl: ENSG00000112983

Variants:

dbSNP: 10902
ClinVar: 10902
TCGA: ENSG00000112983
COSMIC: BRD8

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000112983ENST00000230901Q9H0E9
ENSG00000112983ENST00000254900Q9H0E9
ENSG00000112983ENST00000402931B5MCW3
ENSG00000112983ENST00000411594Q9H0E9
ENSG00000112983ENST00000418329H7C179
ENSG00000112983ENST00000427976H7C026
ENSG00000112983ENST00000428808F8WDX5
ENSG00000112983ENST00000430331C9JV05
ENSG00000112983ENST00000432618F8WBH2
ENSG00000112983ENST00000441656H7C128
ENSG00000112983ENST00000450756F8WCS7
ENSG00000112983ENST00000453824H7C2P4
ENSG00000112983ENST00000454473H7C127
ENSG00000112983ENST00000472478H0Y8F9
ENSG00000112983ENST00000506167H0YAH7
ENSG00000112983ENST00000511898H0YA84
ENSG00000112983ENST00000512140D6RID0

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Chromatin organizationREACTOMER-HSA-4839726
Chromatin modifying enzymesREACTOMER-HSA-3247509
HATs acetylate histonesREACTOMER-HSA-3214847

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
365440232023BRD8 maintains glioblastoma by epigenetic reprogramming of the p53 network.10
365440232023BRD8 maintains glioblastoma by epigenetic reprogramming of the p53 network.10
334767032021The Bromodomain Containing 8 (BRD8) transcriptional network in human lung epithelial cells.6
334767032021The Bromodomain Containing 8 (BRD8) transcriptional network in human lung epithelial cells.6
328607572020BRD8, which is negatively regulated by miR-876-3p, promotes the proliferation and apoptosis resistance of hepatocellular carcinoma cells via KAT5.6
328607572020BRD8, which is negatively regulated by miR-876-3p, promotes the proliferation and apoptosis resistance of hepatocellular carcinoma cells via KAT5.6
302375202018Cellular Depletion of BRD8 Causes p53-Dependent Apoptosis and Induces a DNA Damage Response in Non-Stressed Cells.10
302375202018Cellular Depletion of BRD8 Causes p53-Dependent Apoptosis and Induces a DNA Damage Response in Non-Stressed Cells.10
269400392016MiR-185 attenuates androgen receptor function in prostate cancer indirectly by targeting bromodomain containing 8 isoform 2, an androgen receptor co-activator.14
269400392016MiR-185 attenuates androgen receptor function in prostate cancer indirectly by targeting bromodomain containing 8 isoform 2, an androgen receptor co-activator.14
230640152012The p400/Brd8 chromatin remodeling complex promotes adipogenesis by incorporating histone variant H2A.Z at PPARγ target genes.11
230640152012The p400/Brd8 chromatin remodeling complex promotes adipogenesis by incorporating histone variant H2A.Z at PPARγ target genes.11
197872642009BRD8 is a potential chemosensitizing target for spindle poisons in colorectal cancer therapy.14
197872642009BRD8 is a potential chemosensitizing target for spindle poisons in colorectal cancer therapy.14
165716802006SMAP2, a novel ARF GTPase-activating protein, interacts with clathrin and clathrin assembly protein and functions on the AP-1-positive early endosome/trans-Golgi network.28

Citation

Dessen P

BRD8 (bromodomain containing 8)

Atlas Genet Cytogenet Oncol Haematol. 2010-01-01

Online version: http://atlasgeneticsoncology.org/gene/51290/gene-fusions/tumors-explorer/case-report-explorer/